TNFAIP3 interacting protein 2 (Q21119377)

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mammalian protein found in Homo sapiens

TNIP2
ABIN-2
TNFAIP3-interacting protein 2
A20-binding inhibitor of NF-kappaB activation-2
fetal liver LKB1-interacting protein
A20-binding inhibitor of NF-kappa-B activation 2

Language	Label	Description	Also known as
English	TNFAIP3 interacting protein 2	mammalian protein found in Homo sapiens	TNIP2 ABIN-2 TNFAIP3-interacting protein 2 A20-binding inhibitor of NF-kappaB activation-2 fetal liver LKB1-interacting protein A20-binding inhibitor of NF-kappa-B activation 2

Statements

1 reference

13 November 2019

UniProt protein ID

TSG101 and ALIX binding domain of CEP55, protein family

1 reference

based on heuristic

inferred from protein domain or family

NF-kappa-B essential modulator NEMO, CC2-LZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NEMO, Zinc finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

10 references

8 April 2019

An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

protein kinase binding

determination method

1 reference

8 April 2019

A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

polyubiquitin modification-dependent protein binding

determination method

1 reference

8 April 2019

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

K63-linked polyubiquitin modification-dependent protein binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

biological process

negative regulation of endothelial cell apoptotic process

determination method

1 reference

8 April 2019

ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

regulation of transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFZ5&geneProductId=UniProtKB:Q8NFZ5

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFZ5&geneProductId=UniProtKB:Q8NFZ5

determination method

stress-activated MAPK cascade

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

inflammatory response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

protein deubiquitination

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFZ5

determination method

cellular response to lipopolysaccharide

determination method

interleukin-1-mediated signaling pathway

determination method

TSG101 and ALIX binding domain of CEP55

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8NFZ5

NEMO, Zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8NFZ5

NF-kappa-B essential modulator NEMO, CC2-LZ domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8NFZ5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000321203

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000321203

ENSP00000427613

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427613

ENSP00000426314

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426314

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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