Phosphatidylinositol 4-kinase alpha (Q21119717)

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mammalian protein found in Homo sapiens

phosphatidylinositol 4-kinase, catalytic, alpha
phosphatidylinositol 4-kinase 230
PI4-kinase alpha
phosphatidylinositol 4-kinase alpha
phosphatidylinositol 4-kinase IIII+/-
ptdIns-4-kinase alpha
testicular secretory protein Li 35
phosphatidylinositol 4-kinase, type III, alpha
PI4KA
phosphatidylinositol 4-kinase III alpha

Language	Label	Description	Also known as
English	Phosphatidylinositol 4-kinase alpha	mammalian protein found in Homo sapiens	phosphatidylinositol 4-kinase, catalytic, alpha phosphatidylinositol 4-kinase 230 PI4-kinase alpha phosphatidylinositol 4-kinase alpha phosphatidylinositol 4-kinase IIII+/- ptdIns-4-kinase alpha testicular secretory protein Li 35 phosphatidylinositol 4-kinase, type III, alpha PI4KA phosphatidylinositol 4-kinase III alpha

Statements

1 reference

13 November 2019

UniProt protein ID

Phosphatidylinositol kinase family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42356

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42356

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42356

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42356

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphoinositide 3-kinase, accessory (PIK) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

protein binding

determination method

8 references

8 April 2019

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Plasticity of PI4KIIIα interactions at the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

1-phosphatidylinositol 4-kinase activity

determination method

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

kinase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

cadherin binding

determination method

1 reference

26 September 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

cadherin binding

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

1-phosphatidylinositol 4-kinase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

Golgi-associated vesicle membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

extracellular exosome

determination method

1 reference

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

determination method

1 reference

26 September 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

plasma membrane

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

biological process

signal transduction

determination method

1 reference

8 April 2019

Cloning and characterization of a human phosphatidylinositol 4-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

viral RNA genome replication

determination method

1 reference

8 April 2019

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42356

determination method

actin cytoskeleton organization

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42356&geneProductId=UniProtKB:P42356

determination method

phosphatidylinositol phosphate biosynthetic process

determination method

Phosphoinositide 3-kinase, accessory (PIK) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42356

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42356

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42356

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000255882

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000255882

ENSP00000382162

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000382162

ENSP00000402437

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402437

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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