NADH:ubiquinone oxidoreductase core subunit V2 (Q21120105)

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mammalian protein found in Homo sapiens

NADH-ubiquinone oxidoreductase 24 kDa subunit
NADH-ubiquinone oxidoreductase flavoprotein 2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
complex I, mitochondrial respitory chain, 24 kD subunit
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NDUFV2
complex I 24kDa subunit
NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial
nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit

Language	Label	Description	Also known as
English	NADH:ubiquinone oxidoreductase core subunit V2	mammalian protein found in Homo sapiens	NADH-ubiquinone oxidoreductase 24 kDa subunit NADH-ubiquinone oxidoreductase flavoprotein 2 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial complex I, mitochondrial respitory chain, 24 kD subunit NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa NDUFV2 complex I 24kDa subunit NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit

Statements

1 reference

13 November 2019

UniProt protein ID

NADH-quinone oxidoreductase subunit E-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19404

Thioredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19404

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

NADH dehydrogenase activity

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

electron transfer activity

determination method

1 reference

8 April 2019

Structural organization and chromosomal localization of the human nuclear gene (NDUFV2) for the 24-kDa iron-sulfur subunit of complex I in mitochondrial respiratory chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

4 references

27 March 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

iron-sulfur cluster binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

2 iron, 2 sulfur cluster binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

protein binding

determination method

1 reference

8 April 2019

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

5 references

10 September 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

10 September 2018

Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

10 September 2018

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

3 references

8 April 2019

Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

mitochondrial respiratory chain complex I

determination method

3 references

27 March 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

plasma membrane respiratory chain complex I

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

mitochondrial respiratory chain complex I

determination method

4 references

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

biological process

nervous system development

determination method

1 reference

8 April 2019

Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

cardiac muscle tissue development

determination method

1 reference

8 April 2019

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

mitochondrial respiratory chain complex I assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

mitochondrial electron transport, NADH to ubiquinone

determination method

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

27 March 2018

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

mitochondrial electron transport, NADH to ubiquinone

determination method

4 references

10 September 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

10 September 2018

Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

10 September 2018

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19404&geneProductId=UniProtKB:P19404

determination method

mitochondrial electron transport, NADH to ubiquinone

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19404

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1431

metformin hydrochloride

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1703

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000327268

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000327268

ENSP00000382908

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000382908

ENSP00000461911

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461911

ENSP00000464504

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464504

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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