Nudix hydrolase 16 (Q21120178)

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mammalian protein found in Homo sapiens

testicular tissue protein Li 129
inosine diphosphate phosphatase
nudix (nucleoside diphosphate linked moiety X)-type motif 16
U8 snoRNA-decapping enzyme
nucleoside diphosphate-linked moiety X motif 16
U8 snoRNA-binding protein H29K
m7GpppN-mRNA hydrolase
nudix motif 16
IDPase
NUDT16
3.6.1.64
IDP phosphatase

Language	Label	Description	Also known as
English	Nudix hydrolase 16	mammalian protein found in Homo sapiens	testicular tissue protein Li 129 inosine diphosphate phosphatase nudix (nucleoside diphosphate linked moiety X)-type motif 16 U8 snoRNA-decapping enzyme nucleoside diphosphate-linked moiety X motif 16 U8 snoRNA-binding protein H29K m7GpppN-mRNA hydrolase nudix motif 16 IDPase NUDT16 3.6.1.64 IDP phosphatase

Statements

1 reference

13 November 2019

UniProt protein ID

NUDIX hydrolase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96DE0

NUDIX hydrolase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cobalt ion binding

determination method

1 reference

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

dIDP diphosphatase activity

determination method

1 reference

1 January 2018

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

m7G(5')pppN diphosphatase activity

determination method

5 references

8 April 2019

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Multiple mRNA Decapping Enzymes in Mammalian Cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

protein homodimerization activity

determination method

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

identical protein binding

determination method

1 reference

8 April 2019

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

metalloexopeptidase activity

determination method

1 reference

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

1 reference

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

magnesium ion binding

determination method

3 references

8 April 2019

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

inosine-diphosphatase activity

determination method

1 reference

1 January 2018

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

dITP diphosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

chloride ion binding

determination method

1 reference

8 April 2019

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

phosphodiesterase decapping endonuclease activity

determination method

1 reference

8 April 2019

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Multiple mRNA Decapping Enzymes in Mammalian Cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

2 references

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

6 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

26 September 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

26 September 2017

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

26 September 2017

Multiple mRNA Decapping Enzymes in Mammalian Cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

26 September 2017

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Multiple mRNA Decapping Enzymes in Mammalian Cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

biological process

positive regulation of double-strand break repair

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

nucleobase-containing small molecule catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

IDP catabolic process

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

nucleotide metabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

sno(s)RNA catabolic process

determination method

4 references

8 April 2019

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

negative regulation of rRNA processing

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

positive regulation of cell cycle process

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

adenosine to inosine editing

determination method

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

dephosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

dITP catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

RNA phosphodiester bond hydrolysis, endonucleolytic

determination method

1 reference

8 April 2019

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

determination method

EC enzyme number

3.6.1.64

1 reference

6 January 2016

http://www.uniprot.org/uniprot/Q96DE0.txt?version=118

NUDIX hydrolase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96DE0

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000422375

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422375

ENSP00000429274

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429274

ENSP00000440230

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440230

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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