Leukocyte immunoglobulin like receptor B1 (Q21120812)

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mammalian protein found in Homo sapiens
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
  • ILT-2
  • leukocyte immunoglobulin-like receptor subfamily B member 1
  • myeloid inhibitory receptor 7
  • monocyte/macrophage immunoglobulin-like receptor 7
  • leucocyte Ig-like receptor B1
  • Ig-like transcript 2
  • CD85 antigen-like family member J
  • MIR-7
  • LILRB1
  • Immunoglobulin-like transcript 2
  • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform
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Language Label Description Also known as
English
Leukocyte immunoglobulin like receptor B1
mammalian protein found in Homo sapiens
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
  • ILT-2
  • leukocyte immunoglobulin-like receptor subfamily B member 1
  • myeloid inhibitory receptor 7
  • monocyte/macrophage immunoglobulin-like receptor 7
  • leucocyte Ig-like receptor B1
  • Ig-like transcript 2
  • CD85 antigen-like family member J
  • MIR-7
  • LILRB1
  • Immunoglobulin-like transcript 2
  • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform

Statements

molecular function
MHC class I receptor activity
determination method
IDA
8 references
retrieved
8 April 2019
stated in
Up-regulation of cytolytic functions of human Vδ2-γ T lymphocytes through engagement of ILT2 expressed by tumor target cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
High affinity soluble ILT2 receptor: a potent inhibitor of CD8(+) T cell activation
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
The CD85j+ NK cell subset potently controls HIV-1 replication in autologous dendritic cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
MHC class I protein binding
determination method
IDA
IMP
IPI
11 references
retrieved
8 April 2019
stated in
The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Up-regulation of cytolytic functions of human Vδ2-γ T lymphocytes through engagement of ILT2 expressed by tumor target cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IMP
retrieved
8 April 2019
stated in
The CD85j+ NK cell subset potently controls HIV-1 replication in autologous dendritic cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IMP
retrieved
8 April 2019
stated in
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
High affinity soluble ILT2 receptor: a potent inhibitor of CD8(+) T cell activation
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine nitration in the human leucocyte antigen-G-binding domain of the Ig-like transcript 2 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
retrieved
8 April 2019
stated in
Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IPI
cell component
external side of plasma membrane
determination method
IDA
7 references
retrieved
8 April 2019
stated in
Up-regulation of cytolytic functions of human Vδ2-γ T lymphocytes through engagement of ILT2 expressed by tumor target cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
retrieved
8 April 2019
stated in
Analysis of expression and function of the inhibitory receptor ILT2 in lymphocytes from patients with autoimmune thyroid disease
GOA
curator
UniProt
UniProt protein ID
Q8NHL6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHL6
determination method
IDA
biological process

Identifiers

MeSH descriptor ID
D000075362
subject named as
Leukocyte Immunoglobulin-like Receptor B1
0 references
RefSeq protein ID
Ensembl protein ID
 
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