NFS1 cysteine desulfurase (Q21120945)

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mammalian protein found in Homo sapiens

nitrogen-fixing bacteria S-like protein
nitrogen fixation 1 (S. cerevisiae, homolog)
NFS1
cysteine desulfurase, mitochondrial
NFS1 nitrogen fixation 1 homolog

Language	Label	Description	Also known as
English	NFS1 cysteine desulfurase	mammalian protein found in Homo sapiens	nitrogen-fixing bacteria S-like protein nitrogen fixation 1 (S. cerevisiae, homolog) NFS1 cysteine desulfurase, mitochondrial NFS1 nitrogen fixation 1 homolog

Statements

1 reference

13 November 2019

UniProt protein ID

Pyridoxal phosphate-dependent transferase, major domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y697

Pyridoxal phosphate-dependent transferase domain 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y697

Cysteine desulfurase IscS

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y697

Pyridoxal phosphate-dependent transferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y697

Aminotransferase class V domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aminotransferase class-V, pyridoxal-phosphate binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

iron-sulfur cluster binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

protein binding

determination method

3 references

9 May 2019

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

catalytic activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

pyridoxal phosphate binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

cysteine desulfurase activity

determination method

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

1 January 2018

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

1 January 2018

Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

cysteine desulfurase activity

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

cysteine desulfurase activity

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

determination method

3 references

8 April 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

determination method

3 references

8 April 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

8 April 2019

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

mitochondrial matrix

determination method

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

21 June 2018

Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y697&geneProductId=UniProtKB:Q9Y697

determination method

determination method

4 references

9 May 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

determination method

4 references

9 May 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

biological process

molybdopterin cofactor biosynthetic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

[2Fe-2S] cluster assembly

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

Mo-molybdopterin cofactor biosynthetic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

sulfur amino acid metabolic process

determination method

1 reference

9 May 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

small molecule metabolic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

iron incorporation into metallo-sulfur cluster

determination method

1 reference

9 May 2019

Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

protein-containing complex assembly

determination method

1 reference

9 May 2019

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

iron-sulfur cluster assembly

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y697

determination method

Aminotransferase class-V, pyridoxal-phosphate binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y697

Aminotransferase class V domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y697

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363198

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363198

ENSP00000363205

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363205

ENSP00000380570

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380570

ENSP00000440897

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440897

ENSP00000304740

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000304740

ENSP00000392871

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392871

ENSP00000393482

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393482

ENSP00000393669

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393669

ENSP00000397572

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397572

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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