Nuclear receptor subfamily 2 group C member 2 (Q21120955)

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mammalian protein found in Homo sapiens

orphan receptor TR4
orphan nuclear receptor TR4
orphan nuclear receptor TAK1
testicular nuclear receptor 4
nuclear receptor subfamily 2 group C member 2
Nuclear hormone receptor TR4
NR2C2
Testicular receptor 4

Language	Label	Description	Also known as
English	Nuclear receptor subfamily 2 group C member 2	mammalian protein found in Homo sapiens	orphan receptor TR4 orphan nuclear receptor TR4 orphan nuclear receptor TAK1 testicular nuclear receptor 4 nuclear receptor subfamily 2 group C member 2 Nuclear hormone receptor TR4 NR2C2 Testicular receptor 4

Statements

1 reference

13 November 2019

UniProt protein ID

Nuclear hormone receptor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49116

Zinc finger, NHR/GATA-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49116

nuclear receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49116

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

2 references

DNA-binding transcription factor activity

determination method

3 references

8 April 2019

Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

steroid hormone receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

protein binding

determination method

4 references

8 April 2019

Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

5 references

24 April 2018

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49116&geneProductId=UniProtKB:P49116

determination method

24 April 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49116&geneProductId=UniProtKB:P49116

determination method

8 April 2019

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

determination method

2 references

biological process

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

nervous system development

determination method

1 reference

8 April 2019

Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49116&geneProductId=UniProtKB:P49116

determination method

spermatogenesis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

8 April 2019

Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

steroid hormone mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49116

determination method

signal transduction

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49116&geneProductId=UniProtKB:P49116

determination method

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

nuclear hormone receptor-type zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49116

Nuclear hormone receptor, ligand-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49116

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000320447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000320447

ENSP00000376814

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376814

ENSP00000384463

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384463

ENSP00000388387

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388387

ENSP00000483059

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483059

ENSP00000391473

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391473

ENSP00000401807

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401807

ENSP00000402272

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402272

ENSP00000412473

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412473

ENSP00000413438

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413438

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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