Luteinizing hormone/choriogonadotropin receptor (Q21121615)

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mammalian protein found in Homo sapiens

Luteinizing hormone receptor
lutropin/choriogonadotropin receptor
LHR
LSH-R
LHCGR
hypergonadotropic hypogonadism
lutropin-choriogonadotropic hormone receptor

Language	Label	Description	Also known as
English	Luteinizing hormone/choriogonadotropin receptor	mammalian protein found in Homo sapiens	Luteinizing hormone receptor lutropin/choriogonadotropin receptor LHR LSH-R LHCGR hypergonadotropic hypogonadism lutropin-choriogonadotropic hormone receptor

Statements

1 reference

13 November 2019

UniProt protein ID

Lutropin-choriogonadotropic hormone receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22888

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22888

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

BspA type Leucine rich repeat region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

G protein-coupled peptide receptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

choriogonadotropin hormone binding

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

signal transducer activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

protein-hormone receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

choriogonadotropin hormone receptor activity

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

follicle-stimulating hormone receptor activity

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

luteinizing hormone receptor activity

determination method

3 references

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

determination method

1 reference

8 April 2019

Seven non-contiguous intracellular residues of the lutropin/choriogonadotropin receptor dictate the rate of agonist-induced internalization and its sensitivity to non-visual arrestins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

integral component of plasma membrane

determination method

3 references

8 April 2019

Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

Seven non-contiguous intracellular residues of the lutropin/choriogonadotropin receptor dictate the rate of agonist-induced internalization and its sensitivity to non-visual arrestins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

biological process

G protein-coupled receptor signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

male gonad development

determination method

1 reference

8 April 2019

Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

male genitalia development

determination method

1 reference

8 April 2019

A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

determination method

1 reference

8 April 2019

Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

determination method

1 reference

8 April 2019

Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

positive regulation of inositol trisphosphate biosynthetic process

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

hormone-mediated signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

cellular response to gonadotropin stimulus

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

primary ovarian follicle growth

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

phospholipase C-activating G protein-coupled receptor signaling pathway

determination method

1 reference

16 July 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

follicle-stimulating hormone signaling pathway

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

regulation of osteoclast differentiation

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

luteinizing hormone signaling pathway

determination method

1 reference

16 July 2018

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

positive regulation of adenylate cyclase activity

determination method

1 reference

10 September 2018

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22888&geneProductId=UniProtKB:P22888

determination method

cellular response to luteinizing hormone stimulus

determination method

1 reference

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

ovulation cycle process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22888

determination method

physically interacts with

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201419

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22888

BspA type Leucine rich repeat region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22888

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000294954

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000294954

ENSP00000385406

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385406

ENSP00000385847

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385847

ENSP00000386033

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386033

ENSP00000403748

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403748

PDB structure ID

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P22888.txt?version=182

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P22888.txt?version=182

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

24 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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