glutamyl-prolyl-tRNA synthetase 1 (Q21122161)

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mammalian protein found in Homo sapiens

proline-tRNA ligase
proliferation-inducing gene 32 protein
bifunctional aminoacyl-tRNA synthetase
proliferation-inducing protein 32
glutamatyl-prolyl-tRNA synthetase
prolyl-tRNA synthetase
bifunctional glutamate/proline--tRNA ligase
glutamate tRNA ligase
EPRS
cell proliferation-inducing gene 32 protein
EPRS1
glutaminyl-tRNA synthetase

Language	Label	Description	Also known as
English	glutamyl-prolyl-tRNA synthetase 1	mammalian protein found in Homo sapiens	proline-tRNA ligase proliferation-inducing gene 32 protein bifunctional aminoacyl-tRNA synthetase proliferation-inducing protein 32 glutamatyl-prolyl-tRNA synthetase prolyl-tRNA synthetase bifunctional glutamate/proline--tRNA ligase glutamate tRNA ligase EPRS cell proliferation-inducing gene 32 protein EPRS1 glutaminyl-tRNA synthetase

Statements

1 reference

13 November 2019

UniProt protein ID

Proline-tRNA ligase, class IIa, archaeal-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Anticodon-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Ribosomal protein L25/Gln-tRNA synthetase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Prolyl-tRNA synthetase, class II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

S15/NS1, RNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Glutathione S-transferase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glutathione S-transferase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Prolyl-tRNA synthetase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aminoacyl-tRNA synthetase, class II (G/ P/ S/T), protein family

1 reference

based on heuristic

inferred from protein domain or family

Aminoacyl tRNA synthetases, class II

1 reference

based on heuristic

inferred from protein domain or family

WHEP-TRS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Proline-tRNA ligase, class II, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aminoacyl-tRNA synthetase, class I, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

11 references

8 April 2019

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

The bI4 group I intron binds directly to both its protein splicing partners, a tRNA synthetase and maturase, to facilitate RNA splicing activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

A multifunctional repeated motif is present in human bifunctional tRNA synthetase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

RNA stem-loop binding

determination method

1 reference

8 April 2019

Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

determination method

2 references

catalytic activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

ligase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

determination method

1 reference

8 April 2019

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

glutamate-tRNA ligase activity

determination method

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

proline-tRNA ligase activity

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

zinc ion binding

determination method

1 reference

8 April 2019

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

identical protein binding

determination method

1 reference

8 April 2019

ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

determination method

1 reference

31 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

determination method

4 references

31 October 2017

The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

aminoacyl-tRNA synthetase multienzyme complex

determination method

3 references

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

Dissection of the structural organization of the aminoacyl-tRNA synthetase complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

31 October 2017

Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07814&geneProductId=UniProtKB:P07814

determination method

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

determination method

5 references

8 April 2019

The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

aminoacyl-tRNA synthetase multienzyme complex

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Dissection of the structural organization of the aminoacyl-tRNA synthetase complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

ribonucleoprotein complex

determination method

1 reference

8 April 2019

Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

biological process

regulation of translation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

tRNA aminoacylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

negative regulation of translation

determination method

3 references

8 April 2019

Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

prolyl-tRNA aminoacylation

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

glutamyl-tRNA aminoacylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

protein-containing complex assembly

determination method

1 reference

8 April 2019

The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

long-chain fatty acid import into cell

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

regulation of long-chain fatty acid import into cell

determination method

1 reference

8 April 2019

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07814

determination method

glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

aminoacyl-tRNA synthetase, class I, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Anticodon-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Prolyl-tRNA synthetase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Glutathione S-transferase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

WHEP-TRS domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Aminoacyl-tRNA synthetase, class II domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Proline-tRNA ligase, class II, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07814

Identifiers

MeSH descriptor ID

subject named as

Glutamate-tRNA Ligase

0 references

D08.811.464.263.200.250

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000355890

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355890

ENSP00000477245

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477245

ENSP00000477493

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477493

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

24 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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