Semaphorin 6A (Q21122805)

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mammalian protein found in Homo sapiens

semaphorin VIA
semaphorin-6A
sema VIa
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
semaphorin 6A-1
Semaphorin-6A-1
SEMA6A-1

Language	Label	Description	Also known as
English	Semaphorin 6A	mammalian protein found in Homo sapiens	semaphorin VIA semaphorin-6A sema VIa SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A semaphorin 6A-1 Semaphorin-6A-1 SEMA6A-1

Statements

1 reference

13 November 2019

UniProt protein ID

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H2E6

Sema domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H2E6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H2E6

Sema domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PSI domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Plexin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

1 reference

9 May 2019

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

semaphorin receptor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

chemorepellent activity

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

integral component of membrane

determination method

determination method

1 reference

9 May 2019

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

plasma membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

extracellular space

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

biological process

animal organ morphogenesis

determination method

1 reference

9 May 2019

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

cell surface receptor signaling pathway

determination method

1 reference

9 May 2019

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

cytoskeleton organization

determination method

1 reference

9 May 2019

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

apoptotic process

determination method

1 reference

9 May 2019

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

determination method

1 reference

9 May 2019

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

positive regulation of neuron migration

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

negative regulation of sprouting angiogenesis

determination method

1 reference

9 May 2019

MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

negative regulation of angiogenesis

determination method

1 reference

9 May 2019

MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

negative regulation of cell adhesion involved in sprouting angiogenesis

determination method

1 reference

9 May 2019

MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

cellular response to vascular endothelial growth factor stimulus

determination method

1 reference

9 May 2019

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

negative regulation of ERK1 and ERK2 cascade

determination method

1 reference

9 May 2019

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

negative regulation of vascular endothelial growth factor signaling pathway

determination method

1 reference

9 May 2019

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

neural crest cell migration

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

positive regulation of cell migration

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

negative regulation of axon extension involved in axon guidance

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

negative chemotaxis

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

semaphorin-plexin signaling pathway

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2E6

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H2E6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H2E6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H2E6

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000345512

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000345512

ENSP00000424388

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424388

ENSP00000257414

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000257414

ENSP00000421935

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421935

ENSP00000422275

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422275

ENSP00000422997

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422997

ENSP00000425364

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425364

ENSP00000425553

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425553

PDB structure ID

1 reference

10 November 2015

http://www.uniprot.org/uniprot/O35464.txt?version=136

1 reference

10 November 2015

http://www.uniprot.org/uniprot/O35464.txt?version=136

1 reference

10 November 2015

http://www.uniprot.org/uniprot/O35464.txt?version=136

1 reference

10 November 2015

http://www.uniprot.org/uniprot/O35464.txt?version=136

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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