Melatonin receptor 1B (Q21122997)

http://www.ebi.ac.uk/interpro/protein/P49286

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49286&geneProductId=UniProtKB:P49286

3 references

8 April 2019

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

8 April 2019

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

8 April 2019

Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

G protein-coupled receptor activity

IPI

3 references

10 September 2018

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49286&geneProductId=UniProtKB:P49286

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49286&geneProductId=UniProtKB:P49286

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49286&geneProductId=UniProtKB:P49286

G protein-coupled receptor activity

4 references

8 April 2019

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

integral component of plasma membrane

1 reference

8 April 2019

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

2 references

1 reference

8 April 2019

Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

regulation of insulin secretion

IMP

1 reference

10 September 2018

Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49286&geneProductId=UniProtKB:P49286

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

IMP

1 reference

8 April 2019

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49286&geneProductId=UniProtKB:P49286

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

chemical synaptic transmission

1 reference

8 April 2019

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

negative regulation of cGMP-mediated signaling

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

positive regulation of circadian rhythm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

camera-type eye development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

positive regulation of circadian sleep/wake cycle, non-REM sleep

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

negative regulation of insulin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

negative regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

negative regulation of transmission of nerve impulse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

positive regulation of transmission of nerve impulse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

regulation of neuronal action potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

negative regulation of delayed rectifier potassium channel activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49286

physically interacts with

1 reference

1347

17 August 2016

1 reference

198

17 August 2016

1 reference

1349

17 August 2016

1 reference

1351

17 August 2016

1 reference

224

17 August 2016

1 reference

1356

17 August 2016

1 reference

7393

17 August 2016

1 reference

1363

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL45

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

stated in

InterPro Release 71.0