Microsomal triglyceride transfer protein (Q21122998)

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mammalian protein found in Homo sapiens

microsomal triglyceride transfer protein (large polypeptide, 88kDa)
MTTP
microsomal triglyceride transfer protein large subunit

Language	Label	Description	Also known as
English	Microsomal triglyceride transfer protein	mammalian protein found in Homo sapiens	microsomal triglyceride transfer protein (large polypeptide, 88kDa) MTTP microsomal triglyceride transfer protein large subunit

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein heterodimerization activity

determination method

1 reference

8 April 2019

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

protein binding

determination method

3 references

8 April 2019

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Novel missense MTTP gene mutations causing abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

phospholipid transporter activity

determination method

2 references

16 July 2018

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

16 July 2018

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

lipid transporter activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Novel missense MTTP gene mutations causing abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

phospholipid transporter activity

determination method

3 references

10 September 2018

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

10 September 2018

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

phospholipid transporter activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

receptor complex

determination method

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

endoplasmic reticulum lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

endoplasmic reticulum

determination method

4 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

16 July 2018

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

16 July 2018

Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

16 July 2018

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55157&geneProductId=UniProtKB:P55157

determination method

endoplasmic reticulum

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

basolateral plasma membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

biological process

phospholipid transport

determination method

plasma lipoprotein particle assembly

determination method

lipid metabolism

determination method

1 reference

8 April 2019

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

protein secretion

determination method

1 reference

8 April 2019

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

triglyceride transport

determination method

5 references

8 April 2019

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

8 April 2019

Novel missense MTTP gene mutations causing abetalipoproteinemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

chylomicron assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

very-low-density lipoprotein particle assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

lipoprotein metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

cholesterol homeostasis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55157

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL354541

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2105804

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265517

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000265517

ENSP00000400821

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400821

ENSP00000407350

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407350

ENSP00000422178

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422178

ENSP00000422667

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422667

ENSP00000422782

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422782

ENSP00000424972

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424972

ENSP00000425642

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425642

ENSP00000425987

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425987

ENSP00000426755

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426755

ENSP00000427679

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427679

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

0 references

0 references

WIPO Pearl term ID

0 references

Sitelinks

Wikipedia(6 entries)

dewiki Mikrosomales Triglycerid-Transferprotein
enwiki Microsomal triglyceride transfer protein
frwiki MTTP
jawiki ミクロソームトリグリセリド輸送タンパク質
ttwiki MTTP
ukwiki MTTP

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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