NADH:ubiquinone oxidoreductase subunit A2 (Q21123041)

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mammalian protein found in Homo sapiens

NADH-ubiquinone oxidoreductase B8 subunit
NADH-ubiquinone oxidoreductase subunit CI-B8
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFA2
complex I B8 subunit
CI-B8
Complex I-B8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Language	Label	Description	Also known as
English	NADH:ubiquinone oxidoreductase subunit A2	mammalian protein found in Homo sapiens	NADH-ubiquinone oxidoreductase B8 subunit NADH-ubiquinone oxidoreductase subunit CI-B8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa NDUFA2 complex I B8 subunit CI-B8 Complex I-B8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Statements

1 reference

13 November 2019

UniProt protein ID

Thioredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43678

NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43678

Ribosomal protein/NADH dehydrogenase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

NADH dehydrogenase (ubiquinone) activity

determination method

1 reference

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

mitochondrial respiratory chain complex I

determination method

4 references

24 April 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43678&geneProductId=UniProtKB:O43678

determination method

24 April 2018

Accessory subunits are integral for assembly and function of human mitochondrial complex I.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43678&geneProductId=UniProtKB:O43678

determination method

24 April 2018

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43678&geneProductId=UniProtKB:O43678

determination method

24 April 2018

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43678&geneProductId=UniProtKB:O43678

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

mitochondrial membranes

determination method

1 reference

8 April 2019

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

mitochondrial respiratory chain complex I

determination method

5 references

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

8 April 2019

Accessory subunits are integral for assembly and function of human mitochondrial complex I.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

8 April 2019

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

8 April 2019

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

biological process

mitochondrial electron transport, NADH to ubiquinone

determination method

1 reference

1 January 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43678&geneProductId=UniProtKB:O43678

determination method

blastocyst hatching

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43678

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1431

metformin hydrochloride

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1703

Ribosomal protein/NADH dehydrogenase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43678

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000252102

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000252102

ENSP00000427220

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427220

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

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