Platelet derived growth factor subunit A (Q21123233)

Platelet-derived growth factor, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDGF/VEGF domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Platelet-derived growth factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

platelet-derived growth factor receptor binding

3 references

24 April 2018

Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

platelet-derived growth factor binding

1 reference

8 April 2019

Platelet-derived growth factor: identification of constituent polypeptide chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

protein heterodimerization activity

IPI

1 reference

8 April 2019

Platelet-derived growth factor: identification of constituent polypeptide chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

IPI

growth factor activity

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

identical protein binding

1 reference

24 April 2018

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

platelet-derived growth factor receptor binding

IPI

4 references

8 April 2019

Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

endoplasmic reticulum lumen

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

3 references

8 April 2019

Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Platelet-derived growth factor: purification and partial characterization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

platelet alpha granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

24 April 2018

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

hair follicle development

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

embryonic lung development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

1 reference

8 April 2019

PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

regulation of actin cytoskeleton organization

1 reference

8 April 2019

Mechanism of action and in vivo role of platelet-derived growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of MAP kinase activity

1 reference

24 April 2018

Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of cell migration

1 reference

8 April 2019

Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

platelet degranulation

1 reference

8 April 2019

extracellular matrix organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

Mechanism of action and in vivo role of platelet-derived growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

negative regulation of platelet activation

1 reference

8 April 2019

Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of mesenchymal cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

cell projection assembly

1 reference

8 April 2019

negative regulation of phosphatidylinositol biosynthetic process

1 reference

8 April 2019

Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of protein autophosphorylation

1 reference

24 April 2018

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

positive regulation of ERK1 and ERK2 cascade

1 reference

24 April 2018

Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

regulation of smooth muscle cell migration

1 reference

8 April 2019

Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

animal organ morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

24 April 2018

Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

platelet-derived growth factor receptor signaling pathway

3 references

24 April 2018

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

lung alveolus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of cell division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

actin cytoskeleton organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of MAPK cascade

1 reference

8 April 2019

Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

regulation of glomerular mesangial cell proliferation

1 reference

8 April 2019

Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

1 reference

8 April 2019

Mechanism of action and in vivo role of platelet-derived growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

phosphatidylinositol phosphate biosynthetic process

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

positive regulation of cell population proliferation

6 references

24 April 2018

VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

24 April 2018

Platelet-derived growth factor: identification of constituent polypeptide chains

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04085&geneProductId=UniProtKB:P04085

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of cell population proliferation

7 references

8 April 2019

VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Platelet-derived growth factor: identification of constituent polypeptide chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of cell migration

3 references

8 April 2019

Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

positive regulation of protein autophosphorylation

platelet-derived growth factor receptor signaling pathway

4 references

8 April 2019

A common PDGF receptor is activated by homodimeric A and B forms of PDGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04085

Platelet-derived growth factor, N-terminal

has part(s)

1 reference

Platelet-derived growth factor, conserved site

1 reference

PDGF/VEGF domain

1 reference