Neuropilin 2 (Q21123622)

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mammalian protein found in Homo sapiens

receptor for VEGF165 and semaphorins class3
neuropilin-2
neuropilin-2a(22)
NRP2
vascular endothelial cell growth factor 165 receptor 2
neuropilin-2b(0)
neuropilin-2a(17)

Language	Label	Description	Also known as
English	Neuropilin 2	mammalian protein found in Homo sapiens	receptor for VEGF165 and semaphorins class3 neuropilin-2 neuropilin-2a(22) NRP2 vascular endothelial cell growth factor 165 receptor 2 neuropilin-2b(0) neuropilin-2a(17)

Statements

1 reference

13 November 2019

UniProt protein ID

Spermadhesin, CUB domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60462

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60462

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60462

Galactose-binding-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60462

CUB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MAM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neuropilin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Coagulation factor 5/8 C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

vascular endothelial growth factor-activated receptor activity

determination method

4 references

8 April 2019

Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

The role of neuropilins in cell signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

heparin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

semaphorin receptor activity

determination method

4 references

8 April 2019

Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

The role of neuropilins in cell signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

growth factor binding

determination method

1 reference

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

cytokine binding

determination method

1 reference

8 April 2019

The role of neuropilins in cell signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

protein binding

determination method

1 reference

8 April 2019

Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

identical protein binding

determination method

1 reference

21 June 2018

Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

Neuropilin is a semaphorin III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

determination method

plasma membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

semaphorin receptor complex

determination method

1 reference

8 April 2019

The role of neuropilins in cell signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

integral component of postsynaptic membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

biological process

sympathetic ganglion development

determination method

1 reference

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

semaphorin-plexin signaling pathway involved in neuron projection guidance

determination method

1 reference

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

positive regulation of endothelial cell proliferation

determination method

1 reference

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

vascular endothelial growth factor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

nervous system development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

determination method

4 references

8 April 2019

Neuropilin is a semaphorin III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

The role of neuropilins in cell signalling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

positive regulation of endothelial cell migration

determination method

1 reference

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

sympathetic neuron projection guidance

determination method

1 reference

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

vascular endothelial growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

determination method

1 reference

8 April 2019

Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

nerve development

determination method

1 reference

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

sympathetic neuron projection extension

determination method

1 reference

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

axon extension involved in axon guidance

determination method

1 reference

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

outflow tract septum morphogenesis

determination method

1 reference

27 March 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60462&geneProductId=UniProtKB:O60462

determination method

neural crest cell migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

neuron migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

heart development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

facial nerve structural organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

vestibulocochlear nerve structural organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

ventral trunk neural crest cell migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

negative chemotaxis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

trigeminal ganglion development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

sensory neuron axon guidance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

neural crest cell migration involved in autonomic nervous system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

facioacoustic ganglion development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

dorsal root ganglion morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

cellular response to leukemia inhibitory factor

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

regulation of postsynapse organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60462

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000272849

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000272849

ENSP00000387519

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387519

ENSP00000349632

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349632

ENSP00000350432

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350432

ENSP00000353582

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353582

ENSP00000404279

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404279

ENSP00000407626

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407626

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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