Pim-2 proto-oncogene, serine/threonine kinase (Q21123752)

serine/threonine-protein kinase pim-1/2/3

1 reference

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

protein serine/threonine kinase activity

5 references

31 January 2018

The human Pim-2 proto-oncogene and its testicular expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P1W9&geneProductId=UniProtKB:Q9P1W9

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P1W9&geneProductId=UniProtKB:Q9P1W9

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P1W9&geneProductId=UniProtKB:Q9P1W9

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P1W9&geneProductId=UniProtKB:Q9P1W9

31 January 2018

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P1W9&geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

2 references

protein serine/threonine kinase activity

6 references

1 January 2018

The human Pim-2 proto-oncogene and its testicular expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

protein serine/threonine kinase activity

IBA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

male meiotic nuclear division

1 reference

1 January 2018

The human Pim-2 proto-oncogene and its testicular expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

negative regulation of apoptotic process

IEP

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

The human Pim-2 proto-oncogene and its testicular expression

protein phosphorylation

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 January 2018

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

regulation of mitotic cell cycle

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P1W9&geneProductId=UniProtKB:Q9P1W9

protein autophosphorylation

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

cell population proliferation

1 reference

1 January 2018

The human Pim-2 proto-oncogene and its testicular expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

negative regulation of cell population proliferation

TAS

1 reference

8 April 2019

Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

apoptotic mitochondrial changes

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

positive regulation of macroautophagy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

negative regulation of protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

protein stabilization

3 references

8 April 2019

8 April 2019

Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

G1/S transition of mitotic cell cycle

1 reference

8 April 2019

Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

protein phosphorylation

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

8 April 2019

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P1W9

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5263

language of work or name

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1952329

has part(s)

serine/threonine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference