Methyltransferase like 3 (Q21124024)

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mammalian protein found in Homo sapiens
  • N6-adenosine-methyltransferase 70 kDa subunit
  • mRNA m(6)A methyltransferase
  • mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
  • methyltransferase-like protein 3
  • N6-adenosine-methyltransferase catalytic subunit
  • METTL3
  • adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
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Language Label Description Also known as
English
Methyltransferase like 3
mammalian protein found in Homo sapiens
  • N6-adenosine-methyltransferase 70 kDa subunit
  • mRNA m(6)A methyltransferase
  • mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
  • methyltransferase-like protein 3
  • N6-adenosine-methyltransferase catalytic subunit
  • METTL3
  • adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase

Statements

molecular function
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
determination method
IEA
IDA
IMP
10 references
retrieved
5 June 2018
stated in
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
5 June 2018
stated in
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
5 June 2018
stated in
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
5 June 2018
stated in
N6-methyladenosine-dependent regulation of messenger RNA stability
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
5 June 2018
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Structural insights into the molecular mechanism of the m(6)A writer complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
determination method
IBA
IDA
IEA
IMP
11 references
retrieved
10 September 2018
stated in
N6-methyladenosine-dependent regulation of messenger RNA stability
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
10 September 2018
stated in
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
10 September 2018
stated in
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
10 September 2018
stated in
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
10 September 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
10 September 2018
stated in
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
10 September 2018
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
10 September 2018
stated in
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
10 September 2018
stated in
Structural insights into the molecular mechanism of the m(6)A writer complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IBA
mRNA (N6-adenosine)-methyltransferase activity
determination method
IDA
IMP
8 references
retrieved
8 April 2019
stated in
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
8 April 2019
stated in
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
8 April 2019
stated in
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
8 April 2019
stated in
N6-methyladenosine-dependent regulation of messenger RNA stability
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
8 April 2019
stated in
Structural insights into the molecular mechanism of the m(6)A writer complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
cell component
RNA N6-methyladenosine methyltransferase complex
determination method
IDA
8 references
retrieved
5 June 2018
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
m(6)A RNA methylation promotes XIST-mediated transcriptional repression
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Structural insights into the molecular mechanism of the m(6)A writer complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Interactions, localization and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
nucleus
determination method
IEA
IDA
7 references
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
5 June 2018
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Interactions, localization and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Dynamic m(6)A mRNA methylation directs translational control of heat shock response
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
5 June 2018
stated in
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86U44&geneProductId=UniProtKB:Q86U44
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IEA
retrieved
8 April 2019
stated in
Dynamic m(6)A mRNA methylation directs translational control of heat shock response
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Interactions, localization and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IBA
RNA N6-methyladenosine methyltransferase complex
determination method
IBA
IDA
9 references
retrieved
8 April 2019
stated in
Structural insights into the molecular mechanism of the m(6)A writer complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
m(6)A RNA methylation promotes XIST-mediated transcriptional repression
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Interactions, localization and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IBA
biological process
mRNA methylation
determination method
IDA
IMP
8 references
retrieved
8 April 2019
stated in
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
8 April 2019
stated in
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
8 April 2019
stated in
N6-methyladenosine-dependent regulation of messenger RNA stability
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IMP
retrieved
8 April 2019
stated in
Structural insights into the molecular mechanism of the m(6)A writer complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA
retrieved
8 April 2019
stated in
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
GOA
curator
UniProt
UniProt protein ID
Q86U44
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86U44
determination method
IDA

Identifiers

Freebase ID
/m/0408gd9
0 references
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q21124024&oldid=2023001656"