NLR family pyrin domain containing 12 (Q21124031)

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mammalian protein found in Homo sapiens

NACHT, LRR and PYD domains-containing protein 12
Monarch-1
regulated by nitric oxide
PYRIN-containing APAF1-like protein 7
NLRP12
nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12
monarch 1

Language	Label	Description	Also known as
English	NLR family pyrin domain containing 12	mammalian protein found in Homo sapiens	NACHT, LRR and PYD domains-containing protein 12 Monarch-1 regulated by nitric oxide PYRIN-containing APAF1-like protein 7 NLRP12 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 monarch 1

Statements

1 reference

13 November 2019

UniProt protein ID

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P59046

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P59046

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P59046

NACHT-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NACHT nucleoside triphosphatase family

1 reference

based on heuristic

inferred from protein domain or family

DAPIN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

cysteine-type endopeptidase activator activity involved in apoptotic process

determination method or standard

1 reference

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

protein binding

determination method or standard

4 references

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

8 April 2019

Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

8 April 2019

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

8 April 2019

Evaluation of Nod-like receptor (NLR) effector domain interactions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

determination method or standard

1 reference

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

biological process

dendritic cell migration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

27 March 2018

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59046&geneProductId=UniProtKB:P59046

determination method or standard

regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of Toll signaling pathway

determination method or standard

1 reference

8 April 2019

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of NIK/NF-kappaB signaling

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of inflammatory response

determination method or standard

1 reference

1 January 2018

Mutations in NALP12 cause hereditary periodic fever syndromes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

cellular response to cytokine stimulus

determination method or standard

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59046&geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

27 March 2018

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59046&geneProductId=UniProtKB:P59046

determination method or standard

positive regulation of inflammatory response

determination method or standard

1 reference

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of protein autophosphorylation

determination method or standard

1 reference

8 April 2019

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

positive regulation of MHC class I biosynthetic process

determination method or standard

1 reference

27 March 2018

Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P59046&geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

8 April 2019

Mutations in NALP12 cause hereditary periodic fever syndromes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of signal transduction

determination method or standard

1 reference

8 April 2019

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

positive regulation of NIK/NF-kappaB signaling

determination method or standard

1 reference

8 April 2019

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59046

determination method or standard

negative regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

positive regulation of MHC class I biosynthetic process

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000319377

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000319377

ENSP00000375653

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375653

ENSP00000375655

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375655

ENSP00000341428

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000341428

ENSP00000375652

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375652

PDB structure ID

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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