Nuclear factor of activated T cells 1 (Q21124058)

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mammalian protein found in Homo sapiens

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells 'c'
NFATC1
NFATc
NFAT transcription complex cytosolic component
NF-ATc
nuclear factor of activated T-cells, cytoplasmic 1

Language	Label	Description	Also known as
English	Nuclear factor of activated T cells 1	mammalian protein found in Homo sapiens	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 nuclear factor of activated T-cells 'c' NFATC1 NFATc NFAT transcription complex cytosolic component NF-ATc nuclear factor of activated T-cells, cytoplasmic 1

Statements

1 reference

13 November 2019

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

Rel homology domain (RHD), DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

Nuclear factor of activated T-cells 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

IPT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology domain (RHD), DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

determination method

2 references

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

DNA-binding transcription factor activity

determination method

3 references

24 April 2018

Solution structure of the core NFATC1/DNA complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

24 April 2018

Divergent hTAFII31-binding motifs hidden in activation domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

mitogen-activated protein kinase p38 binding

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

determination method

1 reference

8 April 2019

Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

protein binding

determination method

6 references

8 April 2019

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

10 September 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

chromatin binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

DNA-binding transcription factor activity

determination method

4 references

8 April 2019

Solution structure of the core NFATC1/DNA complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Divergent hTAFII31-binding motifs hidden in activation domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

transcription factor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

24 April 2018

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

transcription regulator complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

biological process

intracellular signal transduction

determination method

1 reference

8 April 2019

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

calcineurin-NFAT signaling cascade

determination method

1 reference

24 April 2018

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

positive regulation of transcription, DNA-templated

determination method

2 references

8 April 2019

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

Fc-epsilon receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

24 April 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

24 April 2018

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

24 April 2018

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95644&geneProductId=UniProtKB:O95644

determination method

Wnt signaling pathway, calcium modulating pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

negative regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

negative regulation of vascular associated smooth muscle cell differentiation

determination method

1 reference

8 April 2019

MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

cytokine production

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

calcineurin-NFAT signaling cascade

determination method

2 references

8 April 2019

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

positive regulation of transcription by RNA polymerase II

determination method

5 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

aortic valve morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

pulmonary valve morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95644

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

Rel homology dimerisation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

Rel homology domain (RHD), DNA-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95644

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000253506

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000253506

ENSP00000316553

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000316553

ENSP00000327850

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000327850

ENSP00000380892

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380892

ENSP00000389377

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389377

ENSP00000442435

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442435

ENSP00000466194

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466194

ENSP00000466489

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466489

ENSP00000467181

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467181

ENSP00000439992

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000439992

ENSP00000467615

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467615

ENSP00000468111

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468111

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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