Sprouty related EVH1 domain containing 1 (Q21124321)

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mammalian protein found in Homo sapiens

protein phosphatase 1, regulatory subunit 147
SPRED1
suppressor of Ras/MAPK activation
sprouty-related, EVH1 domain-containing protein 1

Language	Label	Description	Also known as
English	Sprouty related EVH1 domain containing 1	mammalian protein found in Homo sapiens	protein phosphatase 1, regulatory subunit 147 SPRED1 suppressor of Ras/MAPK activation sprouty-related, EVH1 domain-containing protein 1

Statements

1 reference

13 November 2019

UniProt protein ID

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7Z699

Sprouty protein family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7Z699

WH1/EVH1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

c-Kit-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phosphatase binding

determination method

1 reference

9 May 2019

Docking motif-guided mapping of the interactome of protein phosphatase-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

protein binding

determination method

4 references

9 May 2019

Functional proteomics mapping of a human signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Protein phosphatase 1α interacting proteins in the human brain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Docking motif-guided mapping of the interactome of protein phosphatase-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

protein kinase binding

determination method

3 references

8 April 2019

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

8 April 2019

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

protein kinase binding

determination method

4 references

9 May 2019

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z699&geneProductId=UniProtKB:Q7Z699

determination method

cytoplasmic vesicle

determination method

1 reference

9 May 2019

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

biological process

negative regulation of phosphatase activity

determination method

1 reference

9 May 2019

Docking motif-guided mapping of the interactome of protein phosphatase-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

multicellular organism development

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

fibroblast growth factor receptor signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

regulation of signal transduction

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

vasculogenesis involved in coronary vascular morphogenesis

determination method

1 reference

9 May 2019

MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

negative regulation of cell migration involved in sprouting angiogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

negative regulation of MAPK cascade

determination method

1 reference

9 May 2019

miR-126 regulates angiogenic signaling and vascular integrity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

negative regulation of protein kinase activity

determination method

1 reference

9 May 2019

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

regulation of MAPK cascade

determination method

1 reference

9 May 2019

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

negative regulation of ERK1 and ERK2 cascade

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

negative regulation of peptidyl-threonine phosphorylation

determination method

3 references

9 May 2019

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

negative regulation of angiogenesis

determination method

3 references

9 May 2019

Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

positive regulation of DNA damage response, signal transduction by p53 class mediator

determination method

3 references

9 May 2019

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

regulation of protein deacetylation

determination method

3 references

9 May 2019

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z699

determination method

c-Kit-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7Z699

WH1/EVH1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7Z699

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000299084

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000299084

ENSP00000453680

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453680

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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