Sestrin 2 (Q21125178)

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mammalian protein found in Homo sapiens
  • hypoxia induced gene 95
  • SESN2
  • Hypoxia-induced gene
  • sestrin-2
  • hypoxia-induced
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Language Label Description Also known as
English
Sestrin 2
mammalian protein found in Homo sapiens
  • hypoxia induced gene 95
  • SESN2
  • Hypoxia-induced gene
  • sestrin-2
  • hypoxia-induced

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
SZT2 dictates GATOR control of mTORC1 signalling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
Sestrin2 is a leucine sensor for the mTORC1 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
retrieved
8 April 2019
stated in
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IPI
cell component
GATOR2 complex
determination method
IBA
IDA
6 references
retrieved
8 April 2019
stated in
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IDA
retrieved
8 April 2019
stated in
Sestrin2 is a leucine sensor for the mTORC1 pathway
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IDA
retrieved
8 April 2019
stated in
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IDA
retrieved
8 April 2019
stated in
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IDA
retrieved
8 April 2019
stated in
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IBA
biological process
negative regulation of TORC1 signaling
determination method
IMP
IEA
8 references
retrieved
24 April 2018
stated in
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
24 April 2018
stated in
Hepatoprotective role of Sestrin2 against chronic ER stress
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
24 April 2018
stated in
Sestrin2 is a leucine sensor for the mTORC1 pathway
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
24 April 2018
stated in
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
24 April 2018
stated in
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
24 April 2018
stated in
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
24 April 2018
stated in
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004
determination method
IEA
negative regulation of TORC1 signaling
determination method
IBA
IEA
IMP
9 references
retrieved
8 April 2019
stated in
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
8 April 2019
stated in
Hepatoprotective role of Sestrin2 against chronic ER stress
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
8 April 2019
stated in
Sestrin2 is a leucine sensor for the mTORC1 pathway
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
8 April 2019
stated in
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
8 April 2019
stated in
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
8 April 2019
stated in
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
8 April 2019
stated in
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
GOA
curator
UniProt
UniProt protein ID
P58004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004
determination method
IBA

Identifiers

 
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