VPS16 core subunit of CORVET and HOPS complexes (Q21125670)

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mammalian protein found in Homo sapiens

vacuolar protein sorting protein 16
vacuolar protein sorting 16 homolog
vacuolar protein sorting-associated protein 16 homolog
VPS16, CORVET/HOPS core subunit
VPS16

Language	Label	Description	Also known as
English	VPS16 core subunit of CORVET and HOPS complexes	mammalian protein found in Homo sapiens	vacuolar protein sorting protein 16 vacuolar protein sorting 16 homolog vacuolar protein sorting-associated protein 16 homolog VPS16, CORVET/HOPS core subunit VPS16

Statements

1 reference

13 November 2019

UniProt protein ID

Vacuolar protein sorting-associated protein 16

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H269

Vps16, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H269

Vps16, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Vps16, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

actin filament binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

protein binding

determination method

8 references

8 April 2019

Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

3 references

26 September 2017

SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H269&geneProductId=UniProtKB:Q9H269

determination method

26 September 2017

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H269&geneProductId=UniProtKB:Q9H269

determination method

26 September 2017

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H269&geneProductId=UniProtKB:Q9H269

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

recycling endosome

determination method

1 reference

8 April 2019

SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

late endosome membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

clathrin-coated vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

3 references

determination method

4 references

8 April 2019

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

biological process

regulation of vacuole fusion, non-autophagic

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

endosome to lysosome transport

determination method

1 reference

8 April 2019

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

vacuole organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

autophagosome maturation

determination method

1 reference

8 April 2019

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

protein transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

intracellular protein transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

regulation of SNARE complex assembly

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H269&geneProductId=UniProtKB:Q9H269

determination method

endosomal transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H269

determination method

Vps16, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H269

Vps16, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H269

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000369810

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369810

ENSP00000369836

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369836

ENSP00000409840

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409840

ENSP00000417031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417031

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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