Aldehyde dehydrogenase 5 family member A1 (Q21126464)

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mammalian protein found in Homo sapiens

Aldehyde dehydrogenase family 5 member A1
ALDH5A1
mitochondrial succinate semialdehyde dehydrogenase
succinate-semialdehyde dehydrogenase, mitochondrial
NAD(+)-dependent succinic semialdehyde dehydrogenase

Language	Label	Description	Also known as
English	Aldehyde dehydrogenase 5 family member A1	mammalian protein found in Homo sapiens	Aldehyde dehydrogenase family 5 member A1 ALDH5A1 mitochondrial succinate semialdehyde dehydrogenase succinate-semialdehyde dehydrogenase, mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase

Statements

1 reference

16 January 2019

UniProt protein ID

Aldehyde/histidinol dehydrogenase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51649

Succinate semialdehyde dehydrogenase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51649

Aldehyde dehydrogenase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51649

Aldehyde dehydrogenase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51649

Aldehyde dehydrogenase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldehyde dehydrogenase, glutamic acid active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aldehyde dehydrogenase, cysteine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

8 April 2019

High-level expression and characterization of the recombinant enzyme, and tissue distribution of human succinic semialdehyde dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

succinate-semialdehyde dehydrogenase (NAD+) activity

determination method

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

26 September 2017

Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

26 September 2017

Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

succinate-semialdehyde dehydrogenase [NAD(P)+] activity

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

succinate-semialdehyde dehydrogenase (NAD+) activity

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

mitochondrial matrix

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

determination method

5 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

26 September 2017

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

biological process

gamma-aminobutyric acid catabolic process

determination method

5 references

8 April 2019

Proton MR spectroscopy in succinic semialdehyde dehydrogenase deficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

8 April 2019

Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

gamma-aminobutyric acid metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

post-embryonic development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

glucosylceramide metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

central nervous system development

determination method

1 reference

8 April 2019

Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

protein homotetramerization

determination method

1 reference

8 April 2019

High-level expression and characterization of the recombinant enzyme, and tissue distribution of human succinic semialdehyde dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51649

determination method

glutamate decarboxylation to succinate

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51649&geneProductId=UniProtKB:P51649

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL109

Aldehyde dehydrogenase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51649

Aldehyde dehydrogenase, glutamic acid active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51649

Aldehyde dehydrogenase, cysteine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51649

Identifiers

RefSeq protein ID

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

22 March 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

Ensembl protein ID

ENSP00000314649

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000314649

ENSP00000350191

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000350191

ENSP00000417687

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000417687

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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