Transmembrane serine protease 6 (Q21126609)

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mammalian protein found in Homo sapiens

matriptase-2
TMPRSS6
type II transmembrane serine protease 6
transmembrane protease, serine 6
transmembrane protease serine 6
membrane-bound mosaic serine proteinase matriptase-2

Language	Label	Description	Also known as
English	Transmembrane serine protease 6	mammalian protein found in Homo sapiens	matriptase-2 TMPRSS6 type II transmembrane serine protease 6 transmembrane protease, serine 6 transmembrane protease serine 6 membrane-bound mosaic serine proteinase matriptase-2

Statements

1 reference

13 November 2019

UniProt protein ID

Spermadhesin, CUB domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

LDL receptor-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

peptidase S1A, matriptase-2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

Peptidase S1, PA clan

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

SEA domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

CUB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SEA domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, histidine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, serine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

serine-type peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

protein binding

determination method

1 reference

8 April 2019

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

metalloendopeptidase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80

determination method

serine-type endopeptidase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

intracellular anatomical structure

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80

determination method

extracellular space

determination method

1 reference

8 April 2019

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

plasma membrane

determination method

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80

determination method

27 March 2018

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80

determination method

plasma membrane

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

8 April 2019

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

biological process

membrane protein proteolysis

determination method

1 reference

8 April 2019

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

intracellular signal transduction

determination method

1 reference

1 January 2018

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

determination method

1 reference

1 January 2018

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

determination method

1 reference

27 March 2018

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80

determination method

negative regulation of BMP signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

self proteolysis

determination method

1 reference

8 April 2019

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

extracellular matrix organization

determination method

1 reference

1 January 2018

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

determination method

3 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

1 January 2018

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

extracellular matrix disassembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

collagen catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

determination method

iron ion homeostasis

determination method

3 references

8 April 2019

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

determination method

2 references

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80

determination method

Serine proteases, trypsin family, serine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

low-density lipoprotein (LDL) receptor class A repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

serine proteases, trypsin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

serine proteases, trypsin family, histidine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU80

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000334962

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000334962

ENSP00000371211

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371211

ENSP00000384964

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384964

ENSP00000385453

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385453

ENSP00000392433

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392433

ENSP00000397691

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397691

ENSP00000400317

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400317

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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