RAB7A, member RAS oncogene family (Q21126890)

http://www.ebi.ac.uk/interpro/protein/P51149

http://www.ebi.ac.uk/interpro/protein/C9IZZ0

P-loop containing nucleoside triphosphate hydrolase

2 references

http://www.ebi.ac.uk/interpro/protein/P51149

http://www.ebi.ac.uk/interpro/protein/C9IZZ0

transporter of unknown biochemical mechanism

1 reference

Transporter Classification Database ID

9.A.3.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

17 September 2016

2 references

13 November 2019

20 March 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

3 references

12 references

8 April 2019

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Novel RING E3 ubiquitin ligases in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

A mechanism for retromer endosomal coat complex assembly with cargo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

The Salmonella virulence protein SifA is a G protein antagonist

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

IPI

retromer complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

4 references

31 October 2017

Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

The rab7 GTPase resides on a vesicular compartment connected to lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

5 references

1 January 2018

Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 January 2018

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 January 2018

The rab7 GTPase resides on a vesicular compartment connected to lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 reference

8 April 2019

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

4 references

8 April 2019

Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9IZZ0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9IZZ0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

phagophore assembly site membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

phagocytic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

6 references

31 October 2017

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

autophagosome membrane

1 reference

8 April 2019

1 reference

31 October 2017

Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

IDA

extracellular exosome

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

3 references

8 April 2019

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

secretory granule membrane

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

alveolar lamellar body

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

7 references

8 April 2019

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

IBA

extracellular exosome

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

intracellular anatomical structure

HDA

1 reference

3 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=C9IZZ0

protein to membrane docking

biological process

1 reference

8 April 2019

A mechanism for retromer endosomal coat complex assembly with cargo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

protein targeting to lysosome

IDA

1 reference

8 April 2019

Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

viral release from host cell

1 reference

8 April 2019

Rab7A is required for efficient production of infectious HIV-1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

positive regulation of protein catabolic process

1 reference

8 April 2019

Rab7A is required for efficient production of infectious HIV-1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

phagosome-lysosome fusion

1 reference

31 October 2017

Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 reference

8 April 2019

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

antigen processing and presentation of exogenous peptide antigen via MHC class II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

endosome to lysosome transport

1 reference

31 October 2017

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes

phagosome acidification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

lipid catabolic process

1 reference

8 April 2019

1 reference

8 April 2019

Rab7: roles in membrane trafficking and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

early endosome to late endosome transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

retrograde transport, endosome to Golgi

1 reference

8 April 2019

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

positive regulation of exosomal secretion

1 reference

8 April 2019

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

epidermal growth factor catabolic process

1 reference

8 April 2019

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

positive regulation of viral process

1 reference

8 April 2019

Rab7A is required for efficient production of infectious HIV-1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

neutrophil degranulation

1 reference

8 April 2019

negative regulation of exosomal secretion

1 reference

8 April 2019

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

negative regulation of intralumenal vesicle formation

1 reference

8 April 2019

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7

autophagosome assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51149&geneProductId=UniProtKB:P51149

intracellular protein transport

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

Rab protein signal transduction

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51149

small GTPase mediated signal transduction

IBA

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=C9IZZ0

physically interacts with

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

BioGRID

has part(s)

small GTP-binding protein domain

2 references

http://www.ebi.ac.uk/interpro/protein/P51149

http://www.ebi.ac.uk/interpro/protein/C9IZZ0

Identifiers

MeSH descriptor ID

D000090802

subject named as

rab7 GTP-Binding Proteins

0 references

MeSH tree code

D08.811.277.040.330.300.400.400.600

0 references

D12.776.157.325.515.400.600

0 references

D12.776.476.338.400.400.600

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

20 March 2016

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.3.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023