GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides (Q21128776)

3

Mary X

Ho

1 reference

16 August 2022

Katherine Y Ebright

5

Katherine Y

Ebright

1 reference

16 August 2022

Yon W Ebright

6

Yon W

Ebright

1 reference

16 August 2022

Vladimir Mekler

7

Vladimir

Mekler

1 reference

16 August 2022

Hanif Vahedian-Movahed

8

Hanif

Vahedian-Movahed

1 reference

16 August 2022

Yu Feng

9

Yu

Feng

1 reference

16 August 2022

Ruiheng Yin

10

Ruiheng

Yin

1 reference

16 August 2022

Steve Tuske

11

Steve

Tuske

1 reference

16 August 2022

Herbert Irschik

12

Herbert

Irschik

1 reference

16 August 2022

Rolf Jansen

13

Rolf

Jansen

1 reference

16 August 2022

Sonia Maffioli

14

Sonia

Maffioli

1 reference

16 August 2022

Stefano Donadio

15

Stefano

Donadio

1 reference

16 August 2022

Richard H Ebright

17

Richard H

Structural basis of transcription initiation

Ebright

1 reference

16 August 2022

language of work or name

English

0 references

publication date

2014

0 references

published in

eLife

0 references

volume

3

0 references

page(s)

e02450

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

New target for inhibition of bacterial RNA polymerase: 'switch region'

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

PHENIX: a comprehensive Python-based system for macromolecular structure solution

19 March 2017

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Structures of RNA polymerase-antibiotic complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

The RNA polymerase "switch region" is a target for inhibitors

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

The involvement of the aspartate triad of the active center in all catalytic activities of multisubunit RNA polymerase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Structural basis for substrate loading in bacterial RNA polymerase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Structural mechanism for rifampicin inhibition of bacterial rna polymerase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Features and development of Coot

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Phasercrystallographic software

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Scaling and assessment of data quality

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Mapping and sequencing of mutations in the Escherichia colirpoB gene that lead to rifampicin resistance

19 March 2017

1 reference

https://api.crossref.org/works/10.7554/ELIFE.02450

MOLREP: an Automated Program for Molecular Replacement

22 April 2017

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Structural basis of transcription elongation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Transcriptional infidelity promotes heritable phenotypic change in a bistable gene network

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Recombineering: in vivo genetic engineering in E. coli, S. enterica, and beyond

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Distance-restrained docking of rifampicin and rifamycin SV to RNA polymerase using systematic FRET measurements: developing benchmarks of model quality and reliability

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosome

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Translocation of sigma(70) with RNA polymerase during transcription: fluorescence resonance energy transfer assay for movement relative to DNA.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Transcription activation at class II CAP-dependent promoters: two interactions between CAP and RNA polymerase

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Factors involved in specific transcription by human RNA polymerase II: analysis by a rapid and quantitative in vitro assay

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Prokaryotic and eukaryotic RNA polymerases have homologous core subunits

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Transcriptional proofreading in Escherichia coli

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

On the mechanism of rifampicin inhibition of RNA synthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Activity map of the Escherichia coli RNA polymerase bridge helix

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Supercoiling response of the lac ps promoter in vitro

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Blocking of the Initiation-to-Elongation Transition by a Transdominant RNA Polymerase Mutation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Streptolydigin-resistant mutants in an evolutionarily conserved region of the beta' subunit of Escherichia coli RNA polymerase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Discontinuous movements of DNA and RNA in RNA polymerase accompany formation of a paused transcription complex.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

[Localization of mutation leading to resistance of E. coli RNA polymerase to the antibiotic streptolydigin in the gene rpoB coding for the beta-subunit of the enzyme].

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, biological and biochemical characterization.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

[Nucleotide substitutions in the rpoB gene leading to rifampicin resistance of E. coli RNA polymerase]

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Amino acid changes in conserved regions of the beta-subunit of Escherichia coli RNA polymerase alter transcription pausing and termination.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Mapping of the priming substrate contacts in the active center of Escherichia coli RNA polymerase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

A New Class of Bacterial RNA Polymerase Inhibitor Affects Nucleotide Addition

30 May 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. I. Taxonomy, isolation and characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. II. Structure elucidation

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. Part 3: Chemical derivatization.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

RNA polymerase rifampicin resistance mutations in Escherichia coli: Sequence changes and dominance

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Tethering of the large subunits of Escherichia coli RNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Location, structure, and function of the target of a transcriptional activator protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

Dominant lethal mutations near the 5' substrate binding site affect RNA polymerase propagation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Four contiguous amino acids define the target for streptolydigin resistance in the beta subunit of Escherichia coli RNA polymerase.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994528

Site-specific protein-DNA photocrosslinking. Analysis of bacterial transcription initiation complexes

29 November 2018

1 reference

12 December 2020

A fluorescence-based assay for multisubunit DNA-dependent RNA polymerases

1 reference

12 December 2020

A central role of the RNA polymerase trigger loop in active-site rearrangement during transcriptional pausing

1 reference

12 December 2020

Chemical modifications and biological properties of rifamycins

1 reference

12 December 2020

Mode of action of rifamycin on the RNA polymerase reaction

1 reference

12 December 2020

Primary structure of Escherichia coli RNA polymerase nucleotide substitution in the β subunit gene of the rifampicin resistant rpoB255 mutant

1 reference

12 December 2020

Characterization of ribonucleic acid polymerase-T7 promoter binary complexes

1 reference

12 December 2020

RifR mutations in the beginning of the Escherichia coli rpoB gene

1 reference

12 December 2020

On the treatment of negative intensity observations

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

7 January 2021

inferred from DOI database lookup

Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, bilogical and biochemical characterization.

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.02450

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.7554/ELIFE.02450

1 reference

release_3b232tl3uzfuralx3snqyg5iua

2602873

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/3b232tl3uzfuralx3snqyg5iua

24 November 2022

mapped directly with Wikidata item

2602873

1 reference

1 reference

1 reference