DnaJ heat shock protein family (Hsp40) member A1 (Q21130854)

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mammalian protein found in Homo sapiens

hDj-2
neural precursor cell expressed, developmentally down-regulated 7
heat shock protein, DNAJ-like 2
human DnaJ protein 2
DnaJ (Hsp40) homolog, subfamily A, member 1
dnaJ protein homolog 2
dnaJ homolog subfamily A member 1
HSJ-2
DNAJA1
heat shock 40 kDa protein 4
HSDJ
heat shock protein J2

Language	Label	Description	Also known as
English	DnaJ heat shock protein family (Hsp40) member A1	mammalian protein found in Homo sapiens	hDj-2 neural precursor cell expressed, developmentally down-regulated 7 heat shock protein, DNAJ-like 2 human DnaJ protein 2 DnaJ (Hsp40) homolog, subfamily A, member 1 dnaJ protein homolog 2 dnaJ homolog subfamily A member 1 HSJ-2 DNAJA1 heat shock 40 kDa protein 4 HSDJ heat shock protein J2

Statements

1 reference

13 November 2019

UniProt protein ID

HSP40/DnaJ peptide-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31689

Chaperone J-domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31689

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31689

Heat shock protein DnaJ, cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P31689

Chaperone DnaJ, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Heat shock protein DnaJ, cysteine-rich domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DnaJ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DnaJ domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

chaperone binding

determination method

heat shock protein binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

unfolded protein binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

C3HC4-type RING finger domain binding

determination method

1 reference

8 April 2019

RING finger protein RNF207, a novel regulator of cardiac excitation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

low-density lipoprotein particle receptor binding

determination method

1 reference

8 April 2019

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

Hsp70 protein binding

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

G protein-coupled receptor binding

determination method

1 reference

8 April 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

Tat protein binding

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

ATPase activator activity

determination method

1 reference

8 April 2019

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31689&geneProductId=UniProtKB:P31689

determination method

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31689&geneProductId=UniProtKB:P31689

determination method

26 September 2017

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31689&geneProductId=UniProtKB:P31689

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

ubiquitin ligase complex

determination method

1 reference

8 April 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

cytoplasmic side of endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

extracellular exosome

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

microtubule cytoskeleton

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

determination method

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31689&geneProductId=UniProtKB:P31689

determination method

26 September 2017

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31689&geneProductId=UniProtKB:P31689

determination method

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31689&geneProductId=UniProtKB:P31689

determination method

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

8 April 2019

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

8 April 2019

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

biological process

flagellated sperm motility

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

androgen receptor signaling pathway

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

regulation of protein transport

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

response to heat

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

toxin transport

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

negative regulation of protein ubiquitination

determination method

1 reference

8 April 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

response to unfolded protein

determination method

1 reference

8 April 2019

Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

spermatogenesis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

protein localization to mitochondrion

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

negative regulation of JUN kinase activity

determination method

1 reference

8 April 2019

Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

negative regulation of establishment of protein localization to mitochondrion

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

positive regulation of ATP-dependent activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31689

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000369127

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369127

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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