Cyclin B1 (Q21131192)

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mammalian protein found in Homo sapiens
  • CCNB1
  • G2/mitotic-specific cyclin-B1
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Language Label Description Also known as
English
Cyclin B1
mammalian protein found in Homo sapiens
  • CCNB1
  • G2/mitotic-specific cyclin-B1

Statements

molecular function
protein binding
determination method
IPI
21 references
retrieved
1 January 2018
stated in
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling
GOA
curator
UniProt
UniProt protein ID
P14635
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
GOA
curator
UniProt
UniProt protein ID
P14635
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Cyclin-binding motifs are essential for the function of p21CIP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
retrieved
1 January 2018
stated in
Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IPI
cell component
nucleus
determination method
IBA
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P14635
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IEA
retrieved
1 January 2018
stated in
Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
GOA
curator
UniProt
UniProt protein ID
P14635
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IDA
retrieved
1 January 2018
stated in
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IDA
retrieved
1 January 2018
stated in
Patched1 interacts with cyclin B1 to regulate cell cycle progression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IBA
cytoplasm
determination method
IBA
IDA
IEA
6 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P14635
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IEA
retrieved
1 January 2018
stated in
Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development
GOA
curator
UniProt
UniProt protein ID
P14635
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IDA
retrieved
1 January 2018
stated in
Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
GOA
curator
UniProt
UniProt protein ID
P14635
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IDA
retrieved
1 January 2018
stated in
Patched1 interacts with cyclin B1 to regulate cell cycle progression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14635
determination method
IBA
biological process

Identifiers

 
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