Protein arginine methyltransferase 6 (Q21131677)

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mammalian protein found in Homo sapiens

histone-arginine N-methyltransferase PRMT6
protein arginine N-methyltransferase 6
PRMT6
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
HMT1 hnRNP methyltransferase-like 6

Language	Label	Description	Also known as
English	Protein arginine methyltransferase 6	mammalian protein found in Homo sapiens	histone-arginine N-methyltransferase PRMT6 protein arginine N-methyltransferase 6 PRMT6 heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 HMT1 hnRNP methyltransferase-like 6

Statements

1 reference

13 November 2019

UniProt protein ID

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96LA8

Protein arginine N-methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96LA8

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

histone methyltransferase activity

determination method

1 reference

8 April 2019

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

protein-arginine omega-N monomethyltransferase activity

determination method

3 references

8 April 2019

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Arginine methylation regulates DNA polymerase beta

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

histone methyltransferase activity (H4-R3 specific)

determination method

1 reference

8 April 2019

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

protein-arginine omega-N asymmetric methyltransferase activity

determination method

4 references

27 March 2018

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

27 March 2018

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

27 March 2018

Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

27 March 2018

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

chromatin binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

histone methyltransferase activity (H2A-R3 specific)

determination method

1 reference

8 April 2019

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

protein binding

determination method

5 references

8 April 2019

Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Arginine methylation regulates DNA polymerase beta

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

A Y2H-seq approach defines the human protein methyltransferase interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

histone-arginine N-methyltransferase activity

determination method

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

27 March 2018

H3R42me2a is a histone modification with positive transcriptional effects

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

27 March 2018

Histone arginine methylation keeps RUNX1 target genes in an intermediate state

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

27 March 2018

Thrombospondin-1 is a transcriptional repression target of PRMT6.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

histone-arginine N-methyltransferase activity

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

H3R42me2a is a histone modification with positive transcriptional effects

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Histone arginine methylation keeps RUNX1 target genes in an intermediate state

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Thrombospondin-1 is a transcriptional repression target of PRMT6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

protein-arginine omega-N asymmetric methyltransferase activity

determination method

5 references

8 April 2019

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96LA8&geneProductId=UniProtKB:Q96LA8

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

cellular senescence

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

determination method

histone methylation

determination method

1 reference

8 April 2019

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

base-excision repair

determination method

1 reference

8 April 2019

Arginine methylation regulates DNA polymerase beta

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

protein methylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

histone H4-R3 methylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

regulation of megakaryocyte differentiation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

chromatin organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

histone H3-R2 methylation

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

peptidyl-arginine N-methylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

negative regulation of histone H3-K4 methylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

regulation of signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

determination method

3 references

8 April 2019

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

histone arginine methylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96LA8

determination method

EC enzyme number

2.1.1.125

reason for deprecated rank

deprecated identifier value

1 reference

22 April 2020

2.1.1.321

1 reference

22 April 2020

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000359095

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000359095

ENSP00000497826

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497826

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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