WW domain containing oxidoreductase (Q21132016)

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mammalian protein found in Homo sapiens

WWOX
WW domain-containing oxidoreductase
WW domain-containing protein WWOX
short chain dehydrogenase/reductase family 41C member 1
fragile site FRA16D oxidoreductase

Language	Label	Description	Also known as
English	WW domain containing oxidoreductase	mammalian protein found in Homo sapiens	WWOX WW domain-containing oxidoreductase WW domain-containing protein WWOX short chain dehydrogenase/reductase family 41C member 1 fragile site FRA16D oxidoreductase

Statements

1 reference

13 November 2019

UniProt protein ID

NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZC7

Short-chain dehydrogenase/reductase SDR

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZC7

WW domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZC7

WW domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription coactivator activity

determination method

4 references

27 February 2018

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZC7&geneProductId=UniProtKB:Q9NZC7

determination method

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZC7&geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

protein dimerization activity

determination method

1 reference

8 April 2019

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

protein binding

determination method

7 references

8 April 2019

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

oxidoreductase activity

determination method

3 references

8 April 2019

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

determination method

3 references

8 April 2019

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

determination method

Golgi apparatus

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

plasma membrane

determination method

1 reference

8 April 2019

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

determination method

1 reference

8 April 2019

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

8 April 2019

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

biological process

steroid metabolic process

determination method

1 reference

8 April 2019

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

extrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

negative regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

osteoblast differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

intrinsic apoptotic signaling pathway by p53 class mediator

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC7

determination method

transcription by RNA polymerase II

determination method

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZC7&geneProductId=UniProtKB:Q9NZC7

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZC7

Identifiers

MeSH descriptor ID

subject named as

WW Domain-Containing Oxidoreductase

0 references

D08.811.682.047.820.900.500

0 references

D12.776.624.776.980

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000348119

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348119

ENSP00000384238

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384238

ENSP00000384495

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384495

ENSP00000386161

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386161

ENSP00000454485

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454485

ENSP00000457230

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457230

ENSP00000445210

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445210

ENSP00000454331

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454331

ENSP00000454788

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454788

ENSP00000482648

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000482648

ENSP00000485925

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485925

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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