CD226 molecule (Q21132523)

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mammalian protein found in Homo sapiens

DNAX accessory molecule 1
T lineage-specific activation antigen 1 antigen
CD226
DNAX accessory molecule-1
platelet and T cell activation antigen 1
DNAM-1
adhesion glycoprotein
CD226 antigen

Language	Label	Description	Also known as
English	CD226 molecule	mammalian protein found in Homo sapiens	DNAX accessory molecule 1 T lineage-specific activation antigen 1 antigen CD226 DNAX accessory molecule-1 platelet and T cell activation antigen 1 DNAM-1 adhesion glycoprotein CD226 antigen

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15762

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15762

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin subtype 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CD226.png
1,920 × 975; 391 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

protein binding

determination method

3 references

8 April 2019

Identification of CD112R as a novel checkpoint for human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

8 April 2019

A secreted protein microarray platform for extracellular protein interaction discovery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

8 April 2019

The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

integrin binding

determination method

1 reference

8 April 2019

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

cell adhesion molecule binding

determination method

1 reference

8 April 2019

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

determination method

1 reference

8 April 2019

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

determination method

1 reference

8 April 2019

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

external side of plasma membrane

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

plasma membrane

determination method

2 references

external side of plasma membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

biological process

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

determination method

1 reference

27 March 2018

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

regulation of immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

homophilic cell adhesion via plasma membrane adhesion molecules

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

positive regulation of Fc receptor mediated stimulatory signaling pathway

determination method

1 reference

27 March 2018

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

cell recognition

determination method

1 reference

8 April 2019

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

cytokine production

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

positive regulation of immunoglobulin mediated immune response

determination method

1 reference

27 March 2018

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

signal transduction

determination method

1 reference

8 April 2019

DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

positive regulation of natural killer cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

positive regulation of mast cell activation

determination method

1 reference

27 March 2018

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

positive regulation of interferon-gamma production

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

positive regulation of natural killer cell cytokine production

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

positive regulation of T cell receptor signaling pathway

determination method

1 reference

27 March 2018

Identification of CD112R as a novel checkpoint for human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15762&geneProductId=UniProtKB:Q15762

determination method

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

determination method

cytokine production

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

positive regulation of natural killer cell cytokine production

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

positive regulation of interferon-gamma production

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15762

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000280200

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000280200

ENSP00000461947

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461947

ENSP00000462453

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462453

ENSP00000463152

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463152

ENSP00000463335

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463335

ENSP00000463927

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463927

ENSP00000464084

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464084

ENSP00000464334

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464334

PDB structure ID

0 references

0 references

0 references

0 references

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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