Midline 1 (Q21132775)

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mammalian protein found in Homo sapiens

zinc finger on X and Y, mouse, homolog of
RING-type E3 ubiquitin transferase Midline-1
E3 ubiquitin-protein ligase Midline-1
Midin
RING finger protein Midline-1
Opitz/BBB syndrome
midline 1 RING finger protein
tripartite motif protein TRIM18
tripartite motif-containing protein 18
RING finger protein 59
putative transcription factor XPRF
MID1

Language	Label	Description	Also known as
English	Midline 1	mammalian protein found in Homo sapiens	zinc finger on X and Y, mouse, homolog of RING-type E3 ubiquitin transferase Midline-1 E3 ubiquitin-protein ligase Midline-1 Midin RING finger protein Midline-1 Opitz/BBB syndrome midline 1 RING finger protein tripartite motif protein TRIM18 tripartite motif-containing protein 18 RING finger protein 59 putative transcription factor XPRF MID1

Statements

1 reference

13 November 2019

UniProt protein ID

Fibronectin type III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

RING-type zinc-finger, LisH dimerisation motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

Butyrophylin-like, SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

COS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B30.2/SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B-box, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B-box-type zinc finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

8 April 2019

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

microtubule binding

determination method

1 reference

8 April 2019

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

phosphoprotein binding

determination method

1 reference

8 April 2019

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

protein binding

determination method

5 references

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

8 April 2019

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

identical protein binding

determination method

3 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

8 April 2019

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

8 April 2019

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

microtubule cytoskeleton

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

intracellular anatomical structure

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15344&geneProductId=UniProtKB:O15344

determination method

microtubule associated complex

determination method

1 reference

8 April 2019

The Opitz syndrome gene product, MID1, associates with microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

cytoplasmic microtubule

determination method

1 reference

8 April 2019

Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

biological process

pattern specification process

determination method

1 reference

8 April 2019

Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

interferon-gamma-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

negative regulation of microtubule depolymerization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

protein localization to microtubule

determination method

1 reference

8 April 2019

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

microtubule cytoskeleton organization

determination method

1 reference

8 April 2019

The Opitz syndrome gene product, MID1, associates with microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

positive regulation of stress-activated MAPK cascade

determination method

1 reference

8 April 2019

Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15344

determination method

fibronectin type III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Zinc finger, RING-type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

SPRY-associated

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

B-box, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Butyrophylin-like, SPRY domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

B-box-type zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

RING-type zinc-finger, LisH dimerisation motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

B30.2/SPRY domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15344

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

type of reference

The MID1 gene product in physiology and disease

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000312678

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000312678

ENSP00000370156

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370156

ENSP00000370157

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370157

ENSP00000370159

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370159

ENSP00000370162

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370162

ENSP00000370164

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370164

ENSP00000414521

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414521

ENSP00000391154

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391154

ENSP00000483707

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483707

ENSP00000484712

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484712

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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