Fas associated factor 1 (Q21132817)

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mammalian protein found in Homo sapiens

FAF1
TNFRSF6-associated factor 1
FAS-associated factor 1
UBX domain-containing protein 3A
UBX domain-containing protein 12
UBX domain protein 3A
Fas (TNFRSF6) associated factor 1

Language	Label	Description	Also known as
English	Fas associated factor 1	mammalian protein found in Homo sapiens	FAF1 TNFRSF6-associated factor 1 FAS-associated factor 1 UBX domain-containing protein 3A UBX domain-containing protein 12 UBX domain protein 3A Fas (TNFRSF6) associated factor 1

Statements

1 reference

13 November 2019

UniProt protein ID

Thioredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UNN5

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UNN5

UAS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

UBX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FAS-associated factor 1, UBX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

heat shock protein binding

determination method

1 reference

8 April 2019

Human Fas-associated factor 1 interacts with heat shock protein 70 and negatively regulates chaperone activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

NF-kappaB binding

determination method

1 reference

8 April 2019

Fas-associated Factor-1 Inhibits Nuclear Factor-κB (NF-κB) Activity by Interfering with Nuclear Translocation of the RelA (p65) Subunit of NF-κB

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

ubiquitin binding

determination method

1 reference

8 April 2019

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

protein binding

determination method

3 references

8 April 2019

Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

8 April 2019

Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

8 April 2019

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

protein kinase regulator activity

determination method

1 reference

8 April 2019

FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

protein kinase binding

determination method

1 reference

8 April 2019

FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

determination method

1 reference

8 April 2019

Human Fas-associated factor 1 interacts with heat shock protein 70 and negatively regulates chaperone activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

CD95 death-inducing signaling complex

determination method

1 reference

8 April 2019

Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

nuclear envelope

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

VCP-NPL4-UFD1 AAA ATPase complex

determination method

1 reference

8 April 2019

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

8 April 2019

Human Fas-associated factor 1 interacts with heat shock protein 70 and negatively regulates chaperone activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

8 April 2019

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

biological process

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

positive regulation of cell death

determination method

1 reference

8 April 2019

Human Fas-associated factor 1 interacts with heat shock protein 70 and negatively regulates chaperone activity

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

positive regulation of protein-containing complex assembly

determination method

1 reference

8 April 2019

Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

cytoplasmic sequestering of NF-kappaB

determination method

1 reference

8 April 2019

Fas-associated Factor-1 Inhibits Nuclear Factor-κB (NF-κB) Activity by Interfering with Nuclear Translocation of the RelA (p65) Subunit of NF-κB

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

regulation of cell adhesion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

regulation of protein catabolic process

determination method

1 reference

8 April 2019

Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

Identification and characterization of human Fas associated factor 1, hFAF1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

regulation of protein kinase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

positive regulation of DNA replication

determination method

1 reference

8 April 2019

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNN5

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UNN5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UNN5

FAS-associated factor 1, UBX domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UNN5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000379457

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379457

ENSP00000360843

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360843

ENSP00000434929

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434929

PDB structure ID

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

1 reference

UniProt protein ID

29 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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