MAPK activated protein kinase 2 (Q21132836)

Protein kinase-like domain superfamily

1 reference

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

calmodulin-dependent protein kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

signal transducer activity

1 reference

17 October 2017

The primary structure of a human MAP kinase activated protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

calcium-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

2 references

14 references

8 April 2019

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

The protein interaction landscape of the human CMGC kinase group

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

protein serine/threonine kinase activity

IPI

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

mitogen-activated protein kinase binding

EXP

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

cell component

extracellular exosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

17 October 2017

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

4 references

17 October 2017

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

17 October 2017

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

5 references

8 April 2019

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

17 October 2017

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

1 reference

8 April 2019

The primary structure of a human MAP kinase activated protein kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

regulation of mRNA stability

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

17 October 2017

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

peptidyl-serine phosphorylation

IDA

1 reference

17 October 2017

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

cellular response to vascular endothelial growth factor stimulus

IDA

1 reference

17 October 2017

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

protein autophosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

3'-UTR-mediated mRNA stabilization

3 references

8 April 2019

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

IDA

inner ear development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

Ras protein signal transduction

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49137&geneProductId=UniProtKB:P49137

leukotriene metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

regulation of cellular response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

protein phosphorylation

toll-like receptor signaling pathway

inflammatory response

3 references

3 references

intracellular signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

cellular response to vascular endothelial growth factor stimulus

vascular endothelial growth factor receptor signaling pathway

IMP

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49137

serine/threonine-protein kinase, active site

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016