Voltage dependent anion channel 1 (Q21133152)

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mammalian protein found in Homo sapiens

sperm binding protein 1a
plasmalemmal porin
outer mitochondrial membrane protein porin 1
porin 31HL
porin 31HM
voltage-dependent anion-selective channel protein 1
VDAC1

Language	Label	Description	Also known as
English	Voltage dependent anion channel 1	mammalian protein found in Homo sapiens	sperm binding protein 1a plasmalemmal porin outer mitochondrial membrane protein porin 1 porin 31HL porin 31HM voltage-dependent anion-selective channel protein 1 VDAC1

Statements

1 reference

13 November 2019

UniProt protein ID

Porin domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21796

voltage-dependent anion-selective channel protein 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21796

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

transmembrane transporter binding

determination method or standard

1 reference

9 May 2019

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

anion channel activity

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

voltage-gated anion channel activity

determination method or standard

4 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

protein binding

determination method or standard

13 references

9 May 2019

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Human Bop is a novel BH3-only member of the Bcl-2 protein family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Human Bop is a novel BH3-only member of the Bcl-2 protein family

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

protein kinase binding

determination method or standard

1 reference

9 May 2019

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

identical protein binding

determination method or standard

1 reference

9 May 2019

Structure of the human voltage-dependent anion channel

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

voltage-gated anion channel activity

determination method or standard

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

synaptic vesicle

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

mitochondrial outer membrane

determination method or standard

6 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

3 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

mitochondrial inner membrane

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

mitochondrial nucleoid

determination method or standard

1 reference

9 May 2019

The layered structure of human mitochondrial DNA nucleoids

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

extracellular exosome

determination method or standard

4 references

31 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

31 October 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

mitochondrial permeability transition pore complex

determination method or standard

1 reference

9 May 2019

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

9 May 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

mitochondrial outer membrane

determination method or standard

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

protein-containing complex

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

extracellular exosome

determination method or standard

3 references

9 May 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

biological process

chemical synaptic transmission

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

epithelial cell differentiation

determination method or standard

1 reference

9 May 2019

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

mitochondrial calcium ion transmembrane transport

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

neuron-neuron synaptic transmission

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

behavioral fear response

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

anion transmembrane transport

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

transmembrane transport

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

negative regulation of reactive oxygen species metabolic process

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

apoptotic process

determination method or standard

3 references

9 May 2019

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

9 May 2019

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

regulation of anion transmembrane transport

determination method or standard

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21796&geneProductId=UniProtKB:P21796

determination method or standard

pyruvate metabolic process

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

inorganic anion transport

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21796

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265333

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000265333

ENSP00000378484

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378484

ENSP00000378487

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378487

ENSP00000390129

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390129

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

1 reference

based on heuristic

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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