HECT and RLD domain containing E3 ubiquitin protein ligase 2 (Q21133440)

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mammalian protein found in Homo sapiens

• HECT-type E3 ubiquitin transferase HERC2
• HERC2
• E3 ubiquitin-protein ligase HERC2
• probable E3 ubiquitin-protein ligase HERC2
• hect domain and RCC1-like domain-containing protein 2
• hect domain and RLD 2

edit

Language	Label	Description	Also known as
English	HECT and RLD domain containing E3 ubiquitin protein ligase 2	mammalian protein found in Homo sapiens	HECT-type E3 ubiquitin transferase HERC2 HERC2 E3 ubiquitin-protein ligase HERC2 probable E3 ubiquitin-protein ligase HERC2 hect domain and RCC1-like domain-containing protein 2 hect domain and RLD 2

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95714

part of

HECT, E3 ligase catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

cytochrome b5-like heme/steroid binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Ribosomal protein L2, domain 2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Galactose-binding-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Mib/herc2 domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Zinc finger, ZZ-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

CPH domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HECT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

cytochrome b5-like heme/steroid binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

APC10/DOC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HERC2, APC10 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Mib-herc2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of chromosome condensation, RCC1, protein family

1 reference

based on heuristic

inferred from protein domain or family

Beta-propeller repeat TECPR, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Protein HERC2 PDB 2KEO.png
1,200 × 1,000; 135 KB

1 reference

PDB structure ID

2KEO

HERC2.png
1,920 × 975; 735 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95714

encoded by

HERC2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95714

molecular function

guanyl-nucleotide exchange factor activity

determination method

NAS

1 reference

retrieved

8 April 2019

stated in

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

NAS

zinc ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

metal ion binding

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

SUMO binding

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IDA

ubiquitin-protein transferase activity

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IDA

protein binding

determination method

IPI

4 references

retrieved

8 April 2019

stated in

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IPI

retrieved

8 April 2019

stated in

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IPI

retrieved

8 April 2019

stated in

Network analysis of UBE3A/E6AP-associated proteins provides connections to several distinct cellular processes.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IPI

retrieved

8 April 2019

stated in

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IPI

ubiquitin protein ligase binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IPI

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

ubiquitin protein ligase activity

determination method

IBA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IBA

cell component

cytoplasm

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IDA

membrane

determination method

IDA

1 reference

retrieved

31 October 2017

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IDA

nucleoplasm

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

TAS

mitochondrial inner membrane

determination method

IEA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IEA

centriole

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

cytoskeleton

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

nucleus

determination method

IDA

IEA

2 references

retrieved

31 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

31 October 2017

stated in

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IDA

nucleus

determination method

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IBA

membrane

determination method

HDA

1 reference

retrieved

8 April 2019

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

HDA

biological process

cellular response to DNA damage stimulus

determination method

IDA

IEA

2 references

retrieved

31 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

31 October 2017

stated in

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IDA

protein ubiquitination

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IDA

spermatogenesis

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

intracellular protein transport

determination method

NAS

1 reference

retrieved

8 April 2019

stated in

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

NAS

double-strand break repair via nonhomologous end joining

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

TAS

DNA repair

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

IBA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IBA

regulation of molecular function

determination method

IEA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95714&geneProductId=UniProtKB:O95714

determination method

IEA

cellular response to DNA damage stimulus

determination method

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

GOA

curator

UniProt

UniProt protein ID

O95714

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IBA

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95714

determination method

IBA

has part(s)

Mib-herc2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

APC10/DOC domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

CPH domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Zinc finger, ZZ-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

HECT domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Beta-propeller repeat TECPR

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

cytochrome b5-like heme/steroid binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Regulator of chromosome condensation, RCC1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

HERC2, APC10 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O95714

Identifiers

RefSeq protein ID

NP_004658

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

XP_005268333

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

XP_006720789

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

XP_006720790

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

XP_016878184

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

XP_016878185

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

XP_016878186

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

XP_016878187

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8924

UniProt protein ID

O95714

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O95714

Ensembl protein ID

ENSP00000261609

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000261609

ENSP00000456237

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000456237

ENSP00000488879

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000488879

ENSP00000488506

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000488506

ENSP00000457745

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000457745

ENSP00000477508

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000477508

ENSP00000484177

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000484177

ENSP00000487606

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000487606

ENSP00000496936

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000496936

Google Knowledge Graph ID

/g/12384j9p

0 references

PDB structure ID

2KEO

1 reference

stated in

UniProt

UniProt protein ID

O95714

retrieved

9 August 2016

language of work or name

English

3KCI

1 reference

stated in

UniProt

UniProt protein ID

O95714

retrieved

9 August 2016

language of work or name

English

4L1M

1 reference

stated in

UniProt

UniProt protein ID

O95714

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(7 entries)

edit

• enwiki HERC2
• frwiki HERC2
• nlwiki HERC2
• plwiki HERC2
• rowiki HERC2
• ttwiki HERC2
• ukwiki HERC2

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21133440&oldid=2023020233"