Peroxiredoxin 2 (Q21133501)

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mammalian protein found in Homo sapiens

Thiol-specific antioxidant protein
PRDX2
thiol-specific antioxidant 1
natural killer cell-enhancing factor B
thioredoxin-dependent peroxide reductase 1
thioredoxin peroxidase 1
PRP
NKEF-B
peroxiredoxin-2
TSA
torin
epididymis secretory sperm binding protein Li 2a

Language	Label	Description	Also known as
English	Peroxiredoxin 2	mammalian protein found in Homo sapiens	Thiol-specific antioxidant protein PRDX2 thiol-specific antioxidant 1 natural killer cell-enhancing factor B thioredoxin-dependent peroxide reductase 1 thioredoxin peroxidase 1 PRP NKEF-B peroxiredoxin-2 TSA torin epididymis secretory sperm binding protein Li 2a

Statements

1 reference

13 November 2019

UniProt protein ID

Thioredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32119

Peroxiredoxin, AhpC-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32119

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant, protein family

1 reference

based on heuristic

inferred from protein domain or family

Thioredoxin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peroxiredoxin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

antioxidant activity

determination method

4 references

8 April 2019

Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

peroxidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

thioredoxin peroxidase activity

determination method

5 references

17 October 2017

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

17 October 2017

The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

17 October 2017

Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

17 October 2017

Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

17 October 2017

Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

thioredoxin peroxidase activity

determination method

6 references

1 January 2018

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

1 January 2018

The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

1 January 2018

Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

1 January 2018

Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

1 January 2018

Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

thioredoxin peroxidase activity

determination method

3 references

8 April 2019

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

extracellular exosome

determination method

3 references

17 October 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

extracellular exosome

determination method

3 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

biological process

regulation of apoptotic process

determination method

1 reference

8 April 2019

Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

hydrogen peroxide catabolic process

determination method

1 reference

17 October 2017

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

cell redox homeostasis

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

response to oxidative stress

determination method

removal of superoxide radicals

determination method

1 reference

17 October 2017

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32119&geneProductId=UniProtKB:P32119

determination method

respiratory burst involved in inflammatory response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

response to oxidative stress

determination method

3 references

8 April 2019

Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

regulation of hydrogen peroxide metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

positive regulation of blood coagulation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

negative regulation of lipopolysaccharide-mediated signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

response to lipopolysaccharide

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

T cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

hydrogen peroxide metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

hydrogen peroxide catabolic process

determination method

3 references

8 April 2019

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

negative regulation of T cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

thymus development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

homeostasis of number of cells

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

negative regulation of reactive oxygen species metabolic process

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

negative regulation of extrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

removal of superoxide radicals

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

leukocyte activation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32119

determination method

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32119

Thioredoxin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32119

Peroxiredoxin, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32119

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000301522

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000301522

ENSP00000334063

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000334063

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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