Milk fat globule EGF and factor V/VIII domain containing (Q21133717)

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mammalian protein found in Homo sapiens

• medin
• breast epithelial antigen BA46
• MFG-E8
• lactadherin
• O-acetyl disialoganglioside synthase
• Milk fat globule-EGF factor 8
• sperm surface protein hP47
• sperm associated antigen 10
• MFGE8
• MFGM
• milk fat globule-EGF factor 8 protein
• SED1
• HMFG
• Lactadherin

edit

Language	Label	Description	Also known as
English	Milk fat globule EGF and factor V/VIII domain containing	mammalian protein found in Homo sapiens	medin breast epithelial antigen BA46 MFG-E8 lactadherin O-acetyl disialoganglioside synthase Milk fat globule-EGF factor 8 sperm surface protein hP47 sperm associated antigen 10 MFGE8 MFGM milk fat globule-EGF factor 8 protein SED1 HMFG Lactadherin

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08431

part of

Galactose-binding-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08431

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Coagulation factor 5/8 C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

MFGE8.png
1,920 × 975; 941 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08431

encoded by

MFGE8

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08431

molecular function

phosphatidylserine binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

phosphatidylethanolamine binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

integrin binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

extracellular matrix structural constituent

determination method

HDA

4 references

retrieved

1 January 2018

stated in

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

1 January 2018

stated in

Proteomics characterization of extracellular space components in the human aorta

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

1 January 2018

stated in

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

1 January 2018

stated in

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

HDA

extracellular matrix structural constituent

determination method

IEA

RCA

8 references

retrieved

1 January 2018

stated in

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

retrieved

1 January 2018

stated in

Proteomics characterization of extracellular space components in the human aorta

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

retrieved

1 January 2018

stated in

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

retrieved

1 January 2018

stated in

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

retrieved

1 January 2018

stated in

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

retrieved

1 January 2018

stated in

Proteomics characterization of extracellular space components in the human aorta

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

retrieved

1 January 2018

stated in

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

retrieved

1 January 2018

stated in

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

extracellular matrix structural constituent

determination method

RCA

4 references

retrieved

8 April 2019

stated in

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

retrieved

8 April 2019

stated in

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

retrieved

8 April 2019

stated in

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

retrieved

8 April 2019

stated in

Proteomics characterization of extracellular space components in the human aorta

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

RCA

cell component

external side of plasma membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

extrinsic component of plasma membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

extracellular region

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

extracellular exosome

determination method

IDA

5 references

retrieved

17 October 2017

stated in

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

retrieved

17 October 2017

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

retrieved

17 October 2017

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

retrieved

17 October 2017

stated in

Protein profile of exosomes from trabecular meshwork cells

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

retrieved

17 October 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

extracellular matrix

determination method

IDA

3 references

retrieved

17 October 2017

stated in

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

retrieved

17 October 2017

stated in

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

retrieved

17 October 2017

stated in

Proteomics characterization of extracellular space components in the human aorta

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

extracellular vesicle

determination method

IDA

1 reference

retrieved

17 October 2017

stated in

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

membrane

determination method

IEA

IDA

2 references

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IEA

retrieved

17 October 2017

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

extracellular space

determination method

IDA

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IEA

retrieved

17 October 2017

stated in

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IDA

endoplasmic reticulum lumen

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

TAS

extracellular space

determination method

HDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

retrieved

8 April 2019

stated in

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

membrane

determination method

HDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

retrieved

8 April 2019

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

collagen-containing extracellular matrix

determination method

HDA

4 references

retrieved

8 April 2019

stated in

Proteomics characterization of extracellular space components in the human aorta

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

8 April 2019

stated in

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

8 April 2019

stated in

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

8 April 2019

stated in

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

extracellular exosome

determination method

HDA

4 references

retrieved

8 April 2019

stated in

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

8 April 2019

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

8 April 2019

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

retrieved

8 April 2019

stated in

Protein profile of exosomes from trabecular meshwork cells

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

extracellular vesicle

determination method

HDA

1 reference

retrieved

8 April 2019

stated in

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

HDA

biological process

phagocytosis, recognition

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

angiogenesis

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

positive regulation of phagocytosis

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

positive regulation of apoptotic cell clearance

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IEA

phagocytosis, engulfment

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

cell adhesion

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

single fertilization

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

viral process

determination method

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q08431

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08431&geneProductId=UniProtKB:Q08431

determination method

IEA

post-translational protein modification

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

TAS

apoptotic cell clearance

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08431

determination method

IEA

has part(s)

EGF-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08431

Coagulation factor 5/8 C-terminal domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08431

EGF-like, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08431

Identifiers

RefSeq protein ID

NP_001108086

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4240

NP_001297248

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4240

NP_001297249

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4240

NP_001297250

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4240

NP_005919

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4240

XP_016877695

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4240

XP_024305698

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

4240

UniProt protein ID

Q08431

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q08431

Ensembl protein ID

ENSP00000268150

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000268150

ENSP00000456281

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000456281

ENSP00000268151

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000268151

ENSP00000444332

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000444332

ENSP00000452734

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000452734

ENSP00000452926

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000452926

ENSP00000478952

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000478952

PDB structure ID

2L9L

1 reference

stated in

Swiss-Prot

UniProt

retrieved

10 November 2015

reference URL

http://www.uniprot.org/uniprot/P21956.txt?version=135

 

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21133717&oldid=2023020812"