Profilin 1 (Q21134471)

http://www.ebi.ac.uk/interpro/protein/P07737

Profilin1/2/3, vertebrate

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07737

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Profilin conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

actin monomer binding

1 reference

8 April 2019

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

10 references

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

The association of cortactin with profilin-1 is critical for smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Three-dimensional structure of cofilin bound to monomeric actin derived by structural mass spectrometry data

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

The essential role of profilin in the assembly of actin for microspike formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

The structural basis of actin interaction with multiple WH2/beta-thymosin motif-containing proteins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

adenyl-nucleotide exchange factor activity

IPI

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

4 references

17 October 2017

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

Distinct biochemical characteristics of the two human profilin isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

proline-rich region binding

1 reference

8 April 2019

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

17 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

signaling receptor binding

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

5 references

8 April 2019

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

phosphatidylinositol-4,5-bisphosphate binding

IBA

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

17 October 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

17 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

8 April 2019

The association of cortactin with profilin-1 is critical for smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

17 October 2017

The association of cortactin with profilin-1 is critical for smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

The association of cortactin with profilin-1 is critical for smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

HDA

extracellular exosome

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

HDA

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

positive regulation of actin filament polymerization

biological process

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

positive regulation of ATP-dependent activity

IGI

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

negative regulation of actin filament polymerization

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

positive regulation of ruffle assembly

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

regulation of transcription by RNA polymerase II

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

positive regulation of epithelial cell migration

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

negative regulation of actin filament bundle assembly

IMP

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

positive regulation of actin filament bundle assembly

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

negative regulation of stress fiber assembly

IBA

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

actin cytoskeleton organization

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

Wnt signaling pathway, planar cell polarity pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

response to organic substance

TAS

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

positive regulation of transcription by RNA polymerase II

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

positive regulation of viral transcription

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

positive regulation of DNA metabolic process

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

positive regulation of stress fiber assembly

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

cellular response to growth factor stimulus

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

regulation of actin filament polymerization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

modification of postsynaptic actin cytoskeleton

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

has part(s)

Profilin conserved site

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07737

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016