POU class 4 homeobox 2 (Q21134896)

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mammalian protein found in Homo sapiens

POU domain protein
Brn3b POU domain transcription factor
Brn-3B
brain-specific homeobox/POU domain protein 3B
brain-3B
POU domain, class 4, transcription factor 2
POU4F2

Language	Label	Description	Also known as
English	POU class 4 homeobox 2	mammalian protein found in Homo sapiens	POU domain protein Brn3b POU domain transcription factor Brn-3B brain-specific homeobox/POU domain protein 3B brain-3B POU domain, class 4, transcription factor 2 POU4F2

Statements

1 reference

13 November 2019

UniProt protein ID

Lambda repressor-like, DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12837

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12837

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU-specific domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cro/C1-type helix-turn-helix domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

2 references

DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

3 references

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

chromatin binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

2 references

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

4 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

determination method

5 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

determination method

plasma membrane

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

transcription regulator complex

determination method

1 reference

8 April 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

neuromuscular process controlling balance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

sensory perception of sound

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

determination method

1 reference

8 April 2019

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

spermatogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

intracellular estrogen receptor signaling pathway

determination method

1 reference

8 April 2019

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

retinal ganglion cell axon guidance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

regulation of signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

positive regulation of transcription by RNA polymerase II

determination method

6 references

27 March 2018

Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

positive regulation of programmed cell death

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

cellular response to estradiol stimulus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

intrinsic apoptotic signaling pathway by p53 class mediator

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

positive regulation of transcription regulatory region DNA binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

negative regulation of transcription by RNA polymerase II

determination method

3 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

27 March 2018

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

positive regulation of cardiac muscle cell apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

cellular response to insulin stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

8 April 2019

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

8 April 2019

Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

positive regulation of glucose import

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

cellular response to oxygen levels

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

negative regulation of adipose tissue development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837

determination method

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12837

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12837

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12837

POU-specific domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12837

Cro/C1-type helix-turn-helix domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12837

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000281321

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000281321

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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