POU class 4 homeobox 3 (Q21134903)

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mammalian protein found in Homo sapiens

POU domain, class 4, transcription factor 3
deafness, autosomal dominant 52
POU4F3
deafness, autosomal dominant 42
brain-3C
brain-specific homeobox/POU domain protein 3C
brn-3C

Language	Label	Description	Also known as
English	POU class 4 homeobox 3	mammalian protein found in Homo sapiens	POU domain, class 4, transcription factor 3 deafness, autosomal dominant 52 POU4F3 deafness, autosomal dominant 42 brain-3C brain-specific homeobox/POU domain protein 3C brn-3C

Statements

1 reference

13 November 2019

UniProt protein ID

POU domain, class 4, transcription factor 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

Lambda repressor-like, DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

POU-specific domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cro/C1-type helix-turn-helix domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

DNA-binding transcription factor activity

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

3 references

10 September 2018

Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15319&geneProductId=UniProtKB:Q15319

determination method

8 April 2019

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

8 April 2019

Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

8 April 2019

A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

determination method

visual perception

determination method

1 reference

8 April 2019

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15319&geneProductId=UniProtKB:Q15319

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15319&geneProductId=UniProtKB:Q15319

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

positive regulation of transcription by RNA polymerase II

determination method

2 references

27 March 2018

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15319&geneProductId=UniProtKB:Q15319

determination method

27 March 2018

Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15319&geneProductId=UniProtKB:Q15319

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

vestibulocochlear nerve development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

retinal ganglion cell axon guidance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

inner ear morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

inner ear auditory receptor cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

8 April 2019

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

8 April 2019

Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

neuromuscular process controlling balance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

neuron apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

inner ear receptor cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15319

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

POU-specific domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

Cro/C1-type helix-turn-helix domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15319

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000495718

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495718

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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