RAD18 E3 ubiquitin protein ligase (Q21135006)

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mammalian protein found in Homo sapiens

E3 ubiquitin-protein ligase RAD18
RING-type E3 ubiquitin transferase RAD18
RAD18, S. cerevisiae, homolog
RING finger protein 73
hRAD18
RAD18 homolog
hHR18
RAD18
postreplication repair protein hRAD18p
postreplication repair protein RAD18

Language	Label	Description	Also known as
English	RAD18 E3 ubiquitin protein ligase	mammalian protein found in Homo sapiens	E3 ubiquitin-protein ligase RAD18 RING-type E3 ubiquitin transferase RAD18 RAD18, S. cerevisiae, homolog RING finger protein 73 hRAD18 RAD18 homolog hHR18 RAD18 postreplication repair protein hRAD18p postreplication repair protein RAD18

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

polyubiquitin modification-dependent protein binding

determination method

1 reference

8 April 2019

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

Y-form DNA binding

determination method

1 reference

8 April 2019

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

ubiquitin protein ligase activity

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

damaged DNA binding

determination method

1 reference

8 April 2019

Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

2 references

ubiquitin protein ligase binding

determination method

single-stranded DNA helicase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

protein binding

determination method

10 references

8 April 2019

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

identical protein binding

determination method

1 reference

8 April 2019

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

protein-containing complex binding

determination method

1 reference

8 April 2019

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

single-stranded DNA binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

site of double-strand break

determination method

1 reference

8 April 2019

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

5 references

27 February 2018

Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

27 February 2018

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

27 February 2018

BRCTx is a novel, highly conserved RAD18-interacting protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

27 February 2018

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

replication fork

determination method

1 reference

8 April 2019

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

1 reference

8 April 2019

BRCTx is a novel, highly conserved RAD18-interacting protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

Rad6-Rad18 complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

nuclear inclusion body

determination method

1 reference

8 April 2019

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

6 references

8 April 2019

Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

BRCTx is a novel, highly conserved RAD18-interacting protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

biological process

protein monoubiquitination

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

negative regulation of cell death

determination method

1 reference

8 April 2019

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

positive regulation of chromosome segregation

determination method

1 reference

8 April 2019

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

cellular response to DNA damage stimulus

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

postreplication repair

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NS91&geneProductId=UniProtKB:Q9NS91

determination method

protein autoubiquitination

determination method

1 reference

8 April 2019

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

determination method

3 references

8 April 2019

Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NS91

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264926

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264926

ENSP00000393783

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393783

ENSP00000397852

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397852

ENSP00000399620

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399620

ENSP00000402049

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402049

ENSP00000412054

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412054

ENSP00000412261

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412261

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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