Proteinase 3 (Q2113501)

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mammalian protein found in Homo sapiens

leukocyte proteinase 3
PRTN3
AGP7
myeloblastin
C-ANCA antigen
NP-4
PR-3
PR3
neutrophil proteinase 4
azurophil granule protein 7
serine proteinase, neutrophil
Wegener granulomatosis autoantigen
wegener autoantigen
P29

Language	Label	Description	Also known as
English	Proteinase 3	mammalian protein found in Homo sapiens	leukocyte proteinase 3 PRTN3 AGP7 myeloblastin C-ANCA antigen NP-4 PR-3 PR3 neutrophil proteinase 4 azurophil granule protein 7 serine proteinase, neutrophil Wegener granulomatosis autoantigen wegener autoantigen P29

Statements

1 reference

13 November 2019

UniProt protein ID

0 references

peptidase S1A, chymotrypsin family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24158

Peptidase S1, PA clan

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24158

Serine proteases, trypsin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, histidine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, serine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

protein binding

determination method

3 references

8 April 2019

SERPINB1-mediated checkpoint of inflammatory caspase activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Proteinase 3 is an IL-32 binding protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

serine-type endopeptidase activity

determination method

6 references

8 April 2019

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

extracellular matrix

determination method

1 reference

17 October 2017

Proteomics characterization of extracellular space components in the human aorta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

plasma membrane

determination method

7 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

extracellular region

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

extracellular space

determination method

1 reference

17 October 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

plasma membrane raft

determination method

1 reference

8 April 2019

Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

plasma membrane

determination method

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

biological process

collagen catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

blood coagulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

negative regulation of phagocytosis

determination method

1 reference

8 April 2019

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

mature conventional dendritic cell differentiation

determination method

1 reference

8 April 2019

Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

antimicrobial humoral response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

determination method

4 references

17 October 2017

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

17 October 2017

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24158&geneProductId=UniProtKB:P24158

determination method

membrane protein ectodomain proteolysis

determination method

1 reference

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

cell-cell junction maintenance

determination method

1 reference

8 April 2019

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

neutrophil extravasation

determination method

1 reference

8 April 2019

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

determination method

5 references

8 April 2019

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24158

determination method

Gene Atlas image

PBB GE PRTN3 207341 at fs.png
732 × 530; 10 KB

0 references

serine proteases, trypsin family, histidine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24158

serine proteases, trypsin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24158

Serine proteases, trypsin family, serine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24158

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000234347

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000234347

ENSP00000478977

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478977

ENSP00000478164

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478164

ENSP00000475174

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475174

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(6 entries)

cawiki Proteïnasa 3
cywiki PRTN3
dewiki Proteinase 3
enwiki Proteinase 3
itwiki Proteinasi 3
ukwiki PRTN3

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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