Tribbles pseudokinase 1 (Q21135062)

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mammalian protein found in Homo sapiens

tribbles-like protein 1
G-protein-coupled receptor induced protein
phosphoprotein regulated by mitogenic pathways
TRIB1
G-protein-coupled receptor-induced gene 2 protein
G-protein-coupled receptor-induced protein 2
SKIP1
GIG-2
tribbles homolog 1

Language	Label	Description	Also known as
English	Tribbles pseudokinase 1	mammalian protein found in Homo sapiens	tribbles-like protein 1 G-protein-coupled receptor induced protein phosphoprotein regulated by mitogenic pathways TRIB1 G-protein-coupled receptor-induced gene 2 protein G-protein-coupled receptor-induced protein 2 SKIP1 GIG-2 tribbles homolog 1

Statements

1 reference

13 November 2019

UniProt protein ID

Tribbles homologue 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96RU8

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96RU8

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein kinase activity

determination method

1 reference

8 April 2019

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

protein binding

determination method

1 reference

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

mitogen-activated protein kinase kinase binding

determination method

determination method

1 reference

8 April 2019

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

mitogen-activated protein kinase kinase binding

determination method

3 references

8 April 2019

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

determination method

1 reference

8 April 2019

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

determination method

1 reference

24 April 2018

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96RU8&geneProductId=UniProtKB:Q96RU8

determination method

biological process

negative regulation of smooth muscle cell proliferation

determination method

1 reference

8 April 2019

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

negative regulation of protein kinase activity

determination method

1 reference

8 April 2019

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

positive regulation of macrophage differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

negative regulation of smooth muscle cell migration

determination method

1 reference

8 April 2019

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

negative regulation of DNA-binding transcription factor activity

determination method

3 references

8 April 2019

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

negative regulation of neutrophil differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

negative regulation of lipopolysaccharide-mediated signaling pathway

determination method

1 reference

8 April 2019

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

determination method

1 reference

8 April 2019

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

response to lipopolysaccharide

determination method

3 references

8 April 2019

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

positive regulation of eosinophil differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

regulation of MAP kinase activity

determination method

1 reference

24 April 2018

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96RU8&geneProductId=UniProtKB:Q96RU8

determination method

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

3 references

8 April 2019

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RU8

determination method

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96RU8

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000312150

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000312150

ENSP00000429063

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429063

ENSP00000428879

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428879

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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