The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life (Q21135259)

April 2022 Public Data File from Crossref

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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ppGpp is the major source of growth rate control in E. coli

12 September 2017

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12 September 2017

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ppGpp conjures bacterial virulence

12 September 2017

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12 September 2017

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The compartmentalized bacteria of the planctomycetes-verrucomicrobia-chlamydiae superphylum have membrane coat-like proteins

12 September 2017

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A single molecule view of gene expression.

12 September 2017

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Phylogeny of prokaryotes: does it exist and why should we care?

12 September 2017

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Degradation of ppGpp by nudix pyrophosphatase modulates the transition of growth phase in the bacterium Thermus thermophilus

12 September 2017

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12 September 2017

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The significance of EXDD and RXKD motif conservation in Rel proteins

12 September 2017

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Positive feedback and noise activate the stringent response regulator rel in mycobacteria

12 September 2017

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Still looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulation

12 September 2017

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A charge reversal differentiates (p)ppGpp synthesis by monofunctional and bifunctional Rel proteins

12 September 2017

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Noise in gene expression determines cell fate in Bacillus subtilis

12 September 2017

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The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes

12 September 2017

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The nucleotide-binding site of bacterial translation initiation factor 2 (IF2) as a metabolic sensor

12 September 2017

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The Escherichia coli GTPase CgtAE cofractionates with the 50S ribosomal subunit and interacts with SpoT, a ppGpp synthetase/hydrolase

12 September 2017

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12 September 2017

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cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.

12 September 2017

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Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilis

12 September 2017

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DIVERGE: phylogeny-based analysis for functional-structural divergence of a protein family.

12 September 2017

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Comparative genomics and evolution of genes encoding bacterial (p)ppGpp synthetases/hydrolases (the Rel, RelA and SpoT proteins).

12 September 2017

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Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2).

12 September 2017

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Regulation of Escherichia coli RelA requires oligomerization of the C-terminal domain

12 September 2017

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Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling

12 September 2017

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The HD domain defines a new superfamily of metal-dependent phosphohydrolases

12 September 2017

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The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent (p)ppGpp-synthesizing and -degrading activities.

12 September 2017

1 reference

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Stringent control during carbon starvation of marine Vibrio sp. strain S14: molecular cloning, nucleotide sequence, and deletion of the relA gene

12 September 2017

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Role of Guanine Nucleotides in Protein Synthesis. Elongation Factor G and Guanosine 5′-Triphosphate,3′-Diphosphate

12 September 2017

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MSI and MSII made on ribosome in idling step of protein synthesis

12 September 2017

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The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes

12 September 2017

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Mechanism of the in vitro breakdown of guanosine 5'-diphosphate 3'-diphosphate in Escherichia coli

12 September 2017

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Purine nucleotide pyrophosphotransferase from Streptomyces morookaensis, capable of synthesizing pppApp and pppGpp

12 September 2017

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Transcriptional response of Rickettsia conorii exposed to temperature variation and stress starvation.

12 September 2017

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Guanosine 3',5'-bispyrophosphate (ppGpp) synthesis in cells of Escherichia coli starved for Pi.

27 September 2017

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Analysis of the relA Gene Product of Escherichia coli

27 September 2017

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An ancient P-loop GTPase in rice is regulated by a higher plant-specific regulatory protein

27 September 2017

1 reference

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Bacteria possessing two RelA/SpoT-like proteins have evolved a specific stringent response involving the acyl carrier protein-SpoT interaction.

30 May 2018

1 reference

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Synthesis and hydrolysis of pppGpp in mycobacteria: a ligand mediated conformational switch in Rel.

30 May 2018

1 reference

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Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis

30 May 2018

1 reference

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Dimerization of the RelA protein of Escherichia coli

30 May 2018

1 reference

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Signature sequences in diverse proteins provide evidence of a close evolutionary relationship between the Deinococcus-thermus group and cyanobacteria

30 May 2018

1 reference

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A relA/spoT homologous gene from Streptomyces coelicolor A3(2) controls antibiotic biosynthetic genes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3153485

On the regulation of guanosine tetraphosphate levels in stringent and relaxed strains of Escherichia coli.

30 May 2018

1 reference

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Two Compounds implicated in the Function of the RC Gene of Escherichia coli

30 May 2018

1 reference

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Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus

30 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023479

Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis

21 January 2018

1 reference

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Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene.

21 January 2018

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ppGpp inhibits the activity of Escherichia coli DnaG primase

21 January 2018

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Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected].

21 January 2018

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Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis

21 January 2018

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Maximum-likelihood approach for gene family evolution under functional divergence.

21 January 2018

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A simple statistical method for estimating type-II (cluster-specific) functional divergence of protein sequences.

21 January 2018

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The role of the stringent response in the pathogenesis of bacterial infections.

21 January 2018

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Cost of unneeded proteins in E. coli is reduced after several generations in exponential growth

21 January 2018

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Calcium-activated (p)ppGpp synthetase in chloroplasts of land plants.

21 January 2018

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Three gene products govern (p)ppGpp production by Streptococcus mutans

21 January 2018

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12 December 2020

Guanine nucleotides in protein synthesis. Utilization of pppGpp and dGTP by initiation factor 2 and elongation factor Tu

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12 December 2020

Free 3'-OH group of the terminal adenosine of the tRNA molecule is essential for the synthesis in vitro of guanosine tetraphosphate and pentaphosphate in a ribosomal system from Escherichia coli

1 reference

12 December 2020

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12 December 2020

Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations

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12 December 2020

10.1371/JOURNAL.PONE.0023479

Identifiers

DOI

1 reference

2119386

ADS bibcode

2011PLoSO...623479A

0 references

2119386

1 reference

1 reference

1 reference