Adrenoceptor alpha 2B (Q21141045)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18089

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

22 April 2020

1 reference

22 April 2020

G protein-coupled receptor activity

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

signal transducer activity

alpha2-adrenergic receptor activity

2 references

2 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

adrenergic receptor activity

2 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

5 references

8 April 2019

GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

alpha2-adrenergic receptor activity

IPI

4 references

8 April 2019

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

integral component of membrane

cell component

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

2 references

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

integral component of plasma membrane

1 reference

21 June 2018

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

intracellular anatomical structure

TAS

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

integral component of plasma membrane

1 reference

8 April 2019

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

2 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

G protein-coupled receptor signaling pathway

2 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

adrenergic receptor signaling pathway

1 reference

3 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

regulation of vasoconstriction

2 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

regulation of smooth muscle contraction

2 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

2 references

G protein-coupled receptor signaling pathway

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

5 June 2018

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

activation of protein kinase B activity

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

negative regulation of epinephrine secretion

1 reference

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

1 reference

8 April 2019

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

adenylate cyclase-activating adrenergic receptor signaling pathway

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

positive regulation of neuron differentiation

IBA

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

negative regulation of norepinephrine secretion

positive regulation of MAPK cascade

TAS

NAS

2 references

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

adrenergic receptor signaling pathway

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

G protein-coupled receptor signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

receptor transactivation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

physically interacts with

IBA

1 reference

5443

17 August 2016

1 reference

521

17 August 2016

1 reference

522

17 August 2016

1 reference

520

17 August 2016

1 reference

516

17 August 2016

1 reference

505

17 August 2016

1 reference

124

17 August 2016

1 reference

48

17 August 2016

1 reference

523

17 August 2016

1 reference

33

17 August 2016

1 reference

525

17 August 2016

1 reference

35

17 August 2016

1 reference

37

17 August 2016

1 reference

83

17 August 2016

1 reference

43

17 August 2016

1 reference

7241

17 August 2016

1 reference

7268

17 August 2016

1 reference

502

17 August 2016

1 reference

503

17 August 2016

1 reference

136

17 August 2016

1 reference

52

17 August 2016

1 reference

53

17 August 2016

1 reference

56

17 August 2016

1 reference

7310

17 August 2016

1 reference

499

17 August 2016

1 reference

102

17 August 2016

1 reference

103

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL677

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

apraclonidine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200379

dipivefrin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

oxymetazoline hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200791

phenoxybenzamine hydrochloride

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200787

dexmedetomidine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2106195

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0