Charged multivesicular body protein 2A (Q21143401)

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mammalian protein found in Homo sapiens

putative breast adenocarcinoma marker BC-2
Chromatin-modifying protein 2a
CHMP2A
putative breast adenocarcinoma marker (32kD)
charged multivesicular body protein 2a
hVps2-1
vps2-1
VPS2 homolog A
vacuolar protein sorting-associated protein 2-1
chromatin modifying protein 2A

Language	Label	Description	Also known as
English	Charged multivesicular body protein 2A	mammalian protein found in Homo sapiens	putative breast adenocarcinoma marker BC-2 Chromatin-modifying protein 2a CHMP2A putative breast adenocarcinoma marker (32kD) charged multivesicular body protein 2a hVps2-1 vps2-1 VPS2 homolog A vacuolar protein sorting-associated protein 2-1 chromatin modifying protein 2A

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43633

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein domain specific binding

determination method

1 reference

8 April 2019

ESCRT-III recognition by VPS4 ATPases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

phosphatidylcholine binding

determination method

1 reference

8 April 2019

Helical structures of ESCRT-III are disassembled by VPS4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

protein binding

determination method

16 references

8 April 2019

Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

The Protein Network of HIV Budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Essential role of hIST1 in cytokinesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Helical structures of ESCRT-III are disassembled by VPS4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Structural basis for ESCRT-III protein autoinhibition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Structural basis for ESCRT-III protein autoinhibition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

determination method

2 references

late endosome membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

determination method

1 reference

8 April 2019

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

extracellular exosome

determination method

4 references

3 January 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

nuclear envelope

determination method

1 reference

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

determination method

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

ESCRT III complex

determination method

3 references

8 April 2019

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

multivesicular body

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

extracellular exosome

determination method

3 references

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

biological process

regulation of centrosome duplication

determination method

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

viral budding via host ESCRT complex

determination method

4 references

3 January 2017

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

3 January 2017

ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

3 January 2017

ESCRT requirements for EIAV budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

3 January 2017

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

protein heterooligomerization

determination method

1 reference

8 April 2019

Helical structures of ESCRT-III are disassembled by VPS4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

nucleus organization

determination method

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

viral life cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

establishment of protein localization

determination method

1 reference

8 April 2019

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

negative regulation of centriole elongation

determination method

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

membrane invagination

determination method

1 reference

8 April 2019

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

multivesicular body assembly

determination method

1 reference

8 April 2019

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

negative regulation of cell death

determination method

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

regulation of mitotic spindle assembly

determination method

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

endosomal transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

determination method

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

protein transport

determination method

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

positive regulation of exosomal secretion

determination method

1 reference

8 April 2019

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

septum digestion after cytokinesis

determination method

1 reference

3 January 2017

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

mitotic metaphase plate congression

determination method

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

protein homooligomerization

determination method

1 reference

8 April 2019

Helical structures of ESCRT-III are disassembled by VPS4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

vacuolar transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

regulation of viral process

determination method

1 reference

3 January 2017

The Protein Network of HIV Budding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O43633

determination method

ESCRT III complex disassembly

determination method

1 reference

8 April 2019

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

nuclear membrane reassembly

determination method

1 reference

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

exit from mitosis

determination method

1 reference

8 April 2019

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

determination method

1 reference

8 April 2019

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

endosome transport via multivesicular body sorting pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

late endosome to vacuole transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

midbody abscission

determination method

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43633

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000310440

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000310440

ENSP00000469240

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469240

ENSP00000472680

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472680

ENSP00000469453

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469453

ENSP00000471961

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471961

ENSP00000472097

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472097

Sitelinks

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