Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes (Q21143901)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

0 references

1 reference

4

Andrea Fleig

Andrea

Fleig

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

7

Yongjun Dang

Yongjun

Dang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

10

Reinhold Penner

Reinhold

Penner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Yunzhao R Ren

1

Yunzhao R

Ren

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Fan Pan

2

Fan

Pan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Suhel Parvez

3

Suhel

Parvez

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Curtis R Chong

5

Curtis R

Chong

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jing Xu

6

Jing

Xu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jin Zhang

8

Jin

Zhang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Hongsi Jiang

9

Hongsi

Jiang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jun O Liu

11

Jun O

Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

23 December 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

e4009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

19 January 2020

copyright license

start time

23 December 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

K+ channels as targets for specific immunomodulation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Voltage-gated potassium channels are required for human T lymphocyte activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Double-blind, randomized, controlled clinical trial of clofazimine compared with chloroquine in patients with systemic lupus erythematosus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

TRPM4 regulates calcium oscillations after T cell activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Transcription factors of the NFAT family: regulation and function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Treatment of chronic graft-versus-host disease with clofazimine

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Clofazimine in the treatment of discoid lupus erythematosus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Treatment of pustular psoriasis with clofazimine

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Calcium oscillations increase the efficiency and specificity of gene expression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Targeting effector memory T-cells with Kv1.3 blockers

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Inhibition of angiogenesis by the antifungal drug itraconazole

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

A clinical drug library screen identifies astemizole as an antimalarial agent

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Molecular properties and physiological roles of ion channels in the immune system

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

New immunosuppressive drugs: mechanistic insights and potential therapeutic advances

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Signal transmission between the plasma membrane and nucleus of T lymphocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

The Treatment of Leprosy Today and Tomorrow: The LEPRA Consultation on Chemotherapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

WIN 17317-3: novel nonpeptide antagonist of voltage-activated K+ channels in human T lymphocytes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Adverse effects from multi-drug therapy in leprosy: a Brazilian study

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Purification, visualization, and biophysical characterization of Kv1.3 tetramers

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Pyoderma gangrenosum and ulcerative colitis in black South Africans. Case reports.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Side effects of clofazimine therapy

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602975

Antimycobacterial therapy in Crohn's disease: game over?

29 November 2018

1 reference

12 December 2020

Simple aromatics identified with a NFAT-lacZ transcription assay for the detection of immunosuppressants

1 reference

12 December 2020

Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT)

1 reference

12 December 2020

Controlled trial of antimycobacterial therapy in Crohn's disease. Clofazimine versus placebo

1 reference

12 December 2020

A New Series of Phenazines (Rimino-Compounds) With High Antituberculosis Activity

1 reference

12 December 2020

Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis

1 reference

12 December 2020

Cutaneous disease and drug reactions in HIV infection

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004009

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0004009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

0 references

release_zbcc6wxzfzazjmksvjlh4jkstm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zbcc6wxzfzazjmksvjlh4jkstm

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19104661%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

19104661

1 reference