Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease (Q21144511)

neglected tropical disease

7 February 2021

1 reference

22 October 2019

1 reference

12 November 2019

1 reference

1 reference

Hipólito Nzwalo

1

Hipólito

Nzwalo

1 reference

17 August 2022

Julie Cliff

2

Julie

Cliff

1 reference

21738800

PLoS Neglected Tropical Diseases

17 August 2022

language of work or name

English

0 references

publication date

June 2011

0 references

1 June 2011

6 references

25 April 2019

22 October 2019

12 November 2019

7 February 2021

27 July 2022

22 August 2022

6 references

25 April 2019

22 October 2019

12 November 2019

7 February 2021

27 July 2022

22 August 2022

5

0 references

issue

6

0 references

page(s)

e1051

0 references

copyright license

Creative Commons Attribution 4.0 International

6 references

25 April 2019

22 October 2019

12 November 2019

7 February 2021

27 July 2022

on focus list of Wikimedia project

22 August 2022

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Mantakassa: an epidemic of spastic paraparesis associated with chronic cyanide intoxication in a cassava staple area of Mozambique. 1. Epidemiology and clinical and laboratory findings in patients. Ministry of Health, Mozambique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Neuropathologic study of long term cyanide administration to goats

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Konzo in the Central African Republic

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Association of high cyanide and low sulphur intake in cassava-induced spastic paraparesis

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

19 March 2017

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Konzo, an epidemic upper motor neuron disease studied in Tanzania

21 January 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Cassava cyanogens and konzo, an upper motoneuron disease found in Africa

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Recurrence of konzo in southern Tanzania: Rehabilitation and prevention using the wetting method

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Brain glutathione as a target for aetiological factors in neurolathyrism and konzo

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Assessing diet in populations at risk for konzo and neurolathyrism

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Konzo and continuing cyanide intoxication from cassava in Mozambique

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Etiology of Konzo, epidemic spastic paraparesis associated with cyanogenic glycosides in cassava: role of thiamine deficiency?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agents.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Clinical and etiological profile of tropical ataxic neuropathy in Kerala, South India

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Gender differences in neurological disease: role of estrogens and cytokines

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

New aspects in pathogenesis of konzo: neural cell damage directly caused by linamarin contained in cassava (Manihot esculenta Crantz).

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Konzo outbreak, in the south-west of the Democratic Republic of Congo, 1996.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Metabolism and functions of glutathione in brain.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Ankle clonus and thiocyanate, linamarin, and inorganic sulphate excretion in school children in communities with Konzo, Mozambique.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Geographical and seasonal association between linamarin and cyanide exposure from cassava and the upper motor neurone disease konzo in former Zaire

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Why are so many food plants cyanogenic?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Konzo: a distinct disease entity with selective upper motor neuron damage

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Endemic infantile hypothyroidism in a severe endemic goitre area of central Africa

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Epidemic spastic paraparesis in Bandundu (Zaire).

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Epidemiological evidence from Zaire for a dietary etiology of konzo, an upper motor neuron disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Persistent konzo and cyanogen toxicity from cassava in northern Mozambique

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Long-term follow-up of konzo patients

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Neuropathology of cyanate toxicity in rhesus monkeys. Preliminary report.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Konzo outbreak among refugees from Central African Republic in Eastern region, Cameroon

30 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Appearance of konzo in South-Kivu, a wartorn area in the Democratic Republic of Congo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Konzo, an epidemic spastic paraparesis in Africa, is not associated with antibodies to HTLV-I, HIV, or HIV gag-encoded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Food safety and amino acid balance in processed cassava "Cossettes".

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Rising African cassava production, diseases due to high cyanide intake and control measures

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Uptake of wetting method in Africa to reduce cyanide poisoning and konzo from cassava

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Sodium cyanate alters glutathione homeostasis in rodent brain: relationship to neurodegenerative diseases in protein-deficient malnourished populations in Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

The targets of acetone cyanohydrin neurotoxicity in the rat are not the ones expected in an animal model of konzo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Impact of mitochondrial inhibition on excitability and cytosolic Ca2+ levels in brainstem motoneurones from mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Bioactivation of cyanide to cyanate in sulfur amino acid deficiency: relevance to neurological disease in humans subsisting on cassava

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Changes in blood glutathione concentrations, and in erythrocyte glutathione reductase and glutathione S-transferase activity after running training and after participation in contests

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Impairments, disabilities and handicap pattern in konzo--a non-progressive spastic para/tetraparesis of acute onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001051

Chapter 18 Toxic disorders of the upper motor neuron system

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Neuro-ophthalmologic findings in konzo, an upper motor neuron disorder in Africa.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125150

Purification, characterization, and localization of linamarase in cassava

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21738800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of thiamine deficiency in konzo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21738800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amino acid profile in cassava and its interspecific hybrid

1 reference

https://pubmed.ncbi.nlm.nih.gov/21738800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PNTD.0001051

0 references

PMC publication ID

3125150

0 references