OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions (Q21145339)

16 August 2022

Costas D Maranas

3

Costas D

Maranas

1 reference

16 August 2022

Patrick F Suthers

2

Patrick F

Suthers

1 reference

20419153

PLOS Computational Biology

16 August 2022

language of work or name

English

0 references

publication date

April 2010

0 references

published in

0 references

volume

6

0 references

issue

4

0 references

page(s)

e1000744

0 references

copyright license

Creative Commons Attribution 4.0 International

start time

15 April 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

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Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation

12 September 2017

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Effect of overexpression of Actinobacillus succinogenes phosphoenolpyruvate carboxykinase on succinate production in Escherichia coli

12 September 2017

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Mutation of the ptsG gene results in increased production of succinate in fermentation of glucose by Escherichia coli

12 September 2017

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Metabolic analysis of Escherichia coli in the presence and absence of the carboxylating enzymes phosphoenolpyruvate carboxylase and pyruvate carboxylase

12 September 2017

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Application of mathematical tools for metabolic design of microbial ethanol production

12 September 2017

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Production of succinic acid through overexpression of NAD(+)-dependent malic enzyme in an Escherichia coli mutant

12 September 2017

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Enhanced production of succinic acid by overexpression of phosphoenolpyruvate carboxylase in Escherichia coli.

12 September 2017

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Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli

27 September 2017

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27 September 2017

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30 May 2018

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Optimization in integrated biochemical systems.

21 January 2018

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Optimization of nonlinear biotechnological processes with linear programming: Application to citric acid production by Aspergillus niger.

21 January 2018

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In vivo nuclear magnetic resonance analysis of immobilization effects on glucose metabolism of yeast Saccharomyces cerevisiae

21 January 2018

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A computational procedure for optimal engineering interventions using kinetic models of metabolism.

21 January 2018

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Probing the performance limits of the Escherichia coli metabolic network subject to gene additions or deletions

21 January 2018

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An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems

21 January 2018

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In silico design and adaptive evolution of Escherichia coli for production of lactic acid.

21 January 2018

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Genome-scale in silico aided metabolic analysis and flux comparisons of Escherichia coli to improve succinate production.

21 January 2018

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Development of a metabolic network design and optimization framework incorporating implementation constraints: a succinate production case study

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Exploring the overproduction of amino acids using the bilevel optimization framework OptKnock

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Ensemble modeling for strain development of L-lysine-producing Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Dynamic metabolic engineering for increasing bioprocess productivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Characterization of metabolism in the Fe(III)-reducing organism Geobacter sulfurreducens by constraint-based modeling

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Pairwise calculation of protein solvent-accessible surface areas

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Expression of Ascaris suum malic enzyme in a mutant Escherichia coli allows production of succinic acid from glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Metabolic flux analysis for succinic acid production by recombinant Escherichia coli with amplified malic enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Importance of redox balance on the production of succinic acid by metabolically engineered Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Fed-batch culture of a metabolically engineered Escherichia coli strain designed for high-level succinate production and yield under aerobic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Increasing the acetyl-CoA pool in the presence of overexpressed phosphoenolpyruvate carboxylase or pyruvate carboxylase enhances succinate production in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and productivity

21 January 2018

1 reference

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Efficient succinic acid production from glucose through overexpression of pyruvate carboxylase in an Escherichia coli alcohol dehydrogenase and lactate dehydrogenase mutant

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Batch culture characterization and metabolic flux analysis of succinate-producing Escherichia coli strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000744

Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855329

A novel fermentation pathway in an Escherichia coli mutant producing succinic acid, acetic acid, and ethanol

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20419153

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PCBI.1000744

1 reference

journals/ploscb/RanganathanSM10

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

1 reference

20419153

1 reference